Artigo
Wound-healing and benzodiazepines: does sleep play a role in this relationship?
Fecha
2012-07-01Registro en:
Clinics. Faculdade de Medicina / USP, v. 67, n. 7, p. 827-830, 2012.
1807-5932
S1807-59322012000700020.pdf
S1807-59322012000700020
10.6061/clinics/2012(07)20
WOS:000307723100020
Autor
Egydio, Flavia [UNIFESP]
Pires, Gabriel Natan [UNIFESP]
Tufik, Sergio [UNIFESP]
Andersen, Monica Levy [UNIFESP]
Institución
Resumen
Patients who have suffered burns frequently experience psychological consequences, among which anxiety disorders are prominent. Benzodiazepines are commonly administered to treat these symptoms. The effects of benzodiazepines on healing may not be direct but rather are modulated by alterations of the sleep architecture. This hypothesis is supported by studies that demonstrate the effects of benzodiazepines on the immune system and the inflammatory profile under both normal sleep conditions and during sleep deprivation, particularly rapid eye movement sleep deprivation.