Metilglioxal: uma toxina endógena?

dc.contributorUniversidade de São Paulo (USP)
dc.contributorUniversidade Federal de São Paulo (UNIFESP)
dc.creatorSartori, Adriano
dc.creatorBechara, Etelvino José Henriques [UNIFESP]
dc.date.accessioned2015-06-14T13:41:29Z
dc.date.available2015-06-14T13:41:29Z
dc.date.created2015-06-14T13:41:29Z
dc.date.issued2010-01-01
dc.identifierQuímica Nova. Sociedade Brasileira de Química, v. 33, n. 10, p. 2193-2201, 2010.
dc.identifier0100-4042
dc.identifierhttp://repositorio.unifesp.br/handle/11600/5552
dc.identifierS0100-40422010001000032.pdf
dc.identifierS0100-40422010001000032
dc.identifier10.1590/S0100-40422010001000032
dc.identifierWOS:000286298500032
dc.description.abstractMethylglyoxal is a very reactive α-oxoaldehyde putatively produced by glycolysis, cytochrome P450-catalyzed acetone oxidation and aminoacetone oxidation. Methylglyoxal has been pointed as a substrate for the glyoxalase system ultimately energy-yielding pyruvate, but methylglyoxal is also a toxicant involved in protein aggregation and DNA modification. Controversial hypothesis on methylglyoxal as an anticancer agent, an energy-yielding glycolysis intermediates, and as a regulator of cell division have also been proposed. Methylglyoxal research focuses now on unveiling its biological properties and on the discovery of drugs capable to inhibit its toxic effects, principally in diabetes.
dc.languagepor
dc.publisherSociedade Brasileira de Química
dc.relationQuímica Nova
dc.rightsAcesso aberto
dc.subjectKeywords
dc.subjectmethylglyoxal
dc.subjectglyoxalases
dc.subjectdiabetes
dc.titleMetilglioxal: uma toxina endógena?
dc.typeArtigo


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