dc.contributor | Universidade Federal de São Paulo (UNIFESP) | |
dc.contributor | Universidade Católica do Salvador | |
dc.contributor | Faculdade de Tecnologia e Ciências | |
dc.contributor | National Institute of Respiratory Diseases | |
dc.contributor | Universidade Federal da Bahia Disciplina de Pneumologia | |
dc.contributor | Universidade Federal de Pelotas Programa de Pós-graduação em Epidemiologia | |
dc.contributor | PLATINO Group | |
dc.creator | Rosa, Fernanda Warken [UNIFESP] | |
dc.creator | Pérez-Padilla, Rogelio | |
dc.creator | Camelier, Aquiles Assunção [UNIFESP] | |
dc.creator | Nascimento, Oliver Augusto [UNIFESP] | |
dc.creator | Menezes, Ana Maria Baptista | |
dc.creator | Jardim, José Roberto [UNIFESP] | |
dc.date.accessioned | 2015-06-14T13:37:16Z | |
dc.date.available | 2015-06-14T13:37:16Z | |
dc.date.created | 2015-06-14T13:37:16Z | |
dc.date.issued | 2007-12-01 | |
dc.identifier | Brazilian Journal of Medical and Biological Research. Associação Brasileira de Divulgação Científica, v. 40, n. 12, p. 1615-1621, 2007. | |
dc.identifier | 0100-879X | |
dc.identifier | http://repositorio.unifesp.br/handle/11600/4072 | |
dc.identifier | S0100-879X2007001200004.pdf | |
dc.identifier | S0100-879X2007001200004 | |
dc.identifier | 10.1590/S0100-879X2006005000182 | |
dc.identifier | WOS:000252843900004 | |
dc.description.abstract | The present cross-sectional, population-based study was designed to evaluate the performance of the FEV1/FEV6 ratio for the detection of airway-obstructed subjects compared to the FEV1/FVC <0.70 fixed ratio test, as well as the lower limit of normality (LLN) for 1000 subjects ³40 years of age in the metropolitan area of São Paulo, SP, Brazil. After the exclusion of 37 (3.7%) spirometries, a total of 963 pre-bronchodilator (BD) and 918 post-BD curves were constructed. The majority of the post-BD curves (93.1%) were of very good quality and achieved grade A (762 curves) or B (93 curves). The FEV1/FEV6 and FEV1/FVC ratios were highly correlated (r² = 0.92, P < 0.000). Two receiver operator characteristic curves were constructed in order to express the imbalance between the sensitivity and specificity of the FEV1/FEV6 ratio compared to two FEV1/FVC cut-off points for airway obstruction: equal to 70 (area under the curve = 0.98, P < 0.0001) and the LLN (area under the curve = 0.97, P < 0.0001), in the post-BD curves. According to an FEV1/FVC <0.70, the cut-off point for the FEV1/FEV6 ratio with the highest sum for sensitivity and specificity was 0.75. The FEV1/FEV6 ratio can be considered to be a good alternative to the FEV1/FVC ratio for the diagnosis of airway obstruction, both using a fixed cut-off point or below the LLN as reference. The FEV1/FEV6 ratio has the additional advantage of being an easier maneuver for the subjects and for the lung function technicians, providing a higher reproducibility than traditional spirometry maneuvers. | |
dc.language | eng | |
dc.publisher | Associação Brasileira de Divulgação Científica | |
dc.relation | Brazilian Journal of Medical and Biological Research | |
dc.rights | Acesso aberto | |
dc.subject | Forced expiratory volume in six seconds | |
dc.subject | Airway obstruction | |
dc.subject | Diagnosis | |
dc.subject | Forced vital capacity | |
dc.subject | Pulmonary function tests | |
dc.subject | Spirometry | |
dc.title | Efficacy of the FEV1/FEV6 ratio compared to the FEV1/FVC ratio for the diagnosis of airway obstruction in subjects aged 40 years or over | |
dc.type | Artigo | |