dc.contributorUniversidade Federal de São Paulo (UNIFESP)
dc.creatorWayhs, Mônica Lisboa Chang [UNIFESP]
dc.creatorPatricio, Francy Reis da Silva [UNIFESP]
dc.creatorAmancio, Olga Maria Silverio [UNIFESP]
dc.creatorPedroso, Margareth Zabeu [UNIFESP]
dc.creatorFagundes Neto, Ulysses [UNIFESP]
dc.creatorMorais, Mauro Batista de [UNIFESP]
dc.date.accessioned2015-06-14T13:31:19Z
dc.date.available2015-06-14T13:31:19Z
dc.date.created2015-06-14T13:31:19Z
dc.date.issued2004-11-01
dc.identifierBrazilian Journal of Medical and Biological Research. Associação Brasileira de Divulgação Científica, v. 37, n. 11, p. 1631-1635, 2004.
dc.identifier0100-879X
dc.identifierhttp://repositorio.unifesp.br/handle/11600/2272
dc.identifierS0100-879X2004001100006.pdf
dc.identifierS0100-879X2004001100006
dc.identifier10.1590/S0100-879X2004001100006
dc.identifierWOS:000225128700006
dc.description.abstractThe present study was designed to assess the intestinal absorption of D-xylose and jejunal morphometry in rats with iron-deficiency anemia. Male Wistar rats were randomly divided into a control group (diet containing 50 mg Fe/kg, N = 12) and an anemic group (diet containing <5 mg Fe/kg, N = 12). The animals were housed in individual metabolic cages and deionized water and diet were provided ad libitum for 6 weeks. Hemoglobin and hematocrit were determined at 0, 2, 4, and 6 weeks. At the end of the study the rats were submitted to a D-xylose absorption test (50 mg/100 g body weight) and sacrificed and a jejunal specimen was obtained for morphometric study. At the end of the study the hemoglobin and hematocrit of the anemic rats (8.7 ± 0.9 g/dl and 34.1 ± 2.9%, respectively) were significantly (P < 0.05) lower than those of the controls (13.9 ± 1.4 g/dl and 47.1 ± 1.5%, respectively). There was no statistical difference in D-xylose absorption between the anemic (46.5 ± 7.4%) and control (43.4 ± 9.0%) groups. The anemic animals presented statistically greater villus height (445.3 ± 36.8 µm), mucosal thickness (614.3 ± 56.3 µm) and epithelial surface (5063.0 ± 658.6 µm) than control (371.8 ± 34.3, 526.7 ± 62.3 and 4401.2 ± 704.4 µm, respectively; P < 0.05). The increase in jejunum villus height, mucosal thickness and epithelial surface in rats with iron-deficiency anemia suggests a compensatory intestinal mechanism to increase intestinal iron absorption.
dc.languageeng
dc.publisherAssociação Brasileira de Divulgação Científica
dc.relationBrazilian Journal of Medical and Biological Research
dc.rightsAcesso aberto
dc.subjectIron deficiency
dc.subjectAnemia
dc.subjectJejunal villus height
dc.subjectJejunal mucosal thickness
dc.subjectJejunal epithelial surface
dc.titleMorphological and functional alterations of the intestine of rats with iron-deficiency anemia
dc.typeArtigo


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