Multivariate calibration-assisted high-performance liquid chromatography with dual UV and fluorimetric detection for the analysis of natural and synthetic sex hormones in environmental waters and sediments

dc.creatorPérez, Rocío Laura
dc.creatorEscandar, Graciela Mónica
dc.date2018-06-14T13:52:24Z
dc.date2018-06-14T13:52:24Z
dc.date2016-02
dc.date2018-06-14T13:52:24Z
dc.date2018-06-14T13:52:24Z
dc.date2016-02
dc.date.accessioned2019-05-17T20:24:53Z
dc.date.available2019-05-17T20:24:53Z
dc.identifier0269-7491
dc.identifierhttp://hdl.handle.net/2133/11454
dc.identifierhttp://hdl.handle.net/2133/11454
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/2680118
dc.descriptionA green method is reported based on non-sophisticated instrumental for the quantification of seven natural and synthetic estrogens, three progestagens and one androgen in the presence of real interferences. The method takes advantage of: (1) chromatography, allowing total or partial resolution of a large number of compounds, (2) dual detection, permitting selection of the most appropriate signal for each analyte and, (3) second-order calibration, enabling mathematical resolution of incompletely resolved chromatographic bands and analyte determination in the presence of interferents. Consumption of organic solvents for cleaning, extraction and separation are markedly decreased because of the coupling with MCR-ALS (multivariate curve resolution/alternating least-squares) which allows the successful resolution in the presence of other co-eluting matrix constituents. Rigorous IUPAC detection limits were obtained: 6–24 ng L−1 in water, and 0.1–0.9 ng g−1 in sediments. Relative prediction errors were 2–10% (water) and 1–8% (sediments).
dc.descriptionFil: Pérez, Rocío Laura. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Química Rosario (IQUIR-CONICET); Argentina.
dc.descriptionFil: Escandar, Graciela Mónica. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Química Rosario (IQUIR-CONICET); Argentina.
dc.formatapplication/pdf
dc.languageeng
dc.publisherElsevier
dc.relationhttps://www.sciencedirect.com/science/article/pii/S0269749115301846
dc.relationhttp://dx.doi.org/10.1016/j.envpol.2015.11.024
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.rightsUniversidad Nacional de Rosario
dc.rightsElsevier
dc.rightsPérez, Rocío Laura
dc.rightsEscandar, Graciela Mónica
dc.rightsAtribución-NoComercial-SinDerivadas 4.0 Internacional (CC BY-NC-ND 4.0)
dc.rightsopenAccess
dc.subjectHigh-performance-liquid Chromatography
dc.subjectDual UV-fluorescence Detection
dc.subjectMultivariate Curve Resolution
dc.subjectEndocrine Disruptors
dc.subjectEnvironmental Samples
dc.titleMultivariate calibration-assisted high-performance liquid chromatography with dual UV and fluorimetric detection for the analysis of natural and synthetic sex hormones in environmental waters and sediments


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