Artículos de revistas
Structure/activity of PtII/N,N-Disubstituted-N’-acylthiourea complexes: Anti-tumor and anti-mycobacterium tuberculosis activities
Fecha
2018-06-01Registro en:
Journal of the Brazilian Chemical Society, v. 29, n. 6, p. 1256-1267, 2018.
1678-4790
0103-5053
10.21577/0103-5053.20170222
S0103-50532018000601256
2-s2.0-85046259502
S0103-50532018000601256.pdf
Autor
Universidad de La Habana
Universidade de São Paulo (USP)
Universidade Federal de São Carlos (UFSCar)
Universidade Estadual Paulista (Unesp)
Institución
Resumen
The syntheses, characterization, cytotoxicity against tumor cells and anti-Mycobacterium tuberculosis activity assays of PtII/PPh3/N,N-disubstituted-N’-acylthioureas complexes with general formulae [Pt(PPh3)2(L)]PF6, PPh3 = triphenylphosphine; L = N,N-disubstituted-N’-acylthiourea, are here reported. The complexes were characterized by elemental analysis, molar conductivity, infrared (IR), nuclear magnetic resonance (NMR) (1H, 13C{1H} and 31P{1H}) spectroscopy. The 31P{1H} NMR data are consistent with the presence of two PPh3 ligands cis to each other position, and one N,N-disubstituted-N’-acylthiourea coordinated to the metal through O and S, in a chelate form. The structures of the complexes were determined by X-ray crystallography, forming distorted square-planar structures. The complexes were tested in human cell lines carcinomas and also screened with respect to their anti-Mycobacterium tuberculosis activity (H37RvATCC 27294). It was found that complexes with N,N-disubstituted-N’-acylthiourea containing open and small chains as R2 groups show higher cytotoxic and higher anti-Mycobacterium tuberculosis activity than those containing rings in this position.