dc.contributor | Universidade Estadual Paulista (Unesp) | |
dc.contributor | Universidade Braz Cubas | |
dc.contributor | Heliopolis Hospital | |
dc.date.accessioned | 2018-12-11T17:32:33Z | |
dc.date.available | 2018-12-11T17:32:33Z | |
dc.date.created | 2018-12-11T17:32:33Z | |
dc.date.issued | 2017-10-01 | |
dc.identifier | Journal of Oral Pathology and Medicine, v. 46, n. 9, p. 840-845, 2017. | |
dc.identifier | 1600-0714 | |
dc.identifier | 0904-2512 | |
dc.identifier | http://hdl.handle.net/11449/178886 | |
dc.identifier | 10.1111/jop.12590 | |
dc.identifier | 2-s2.0-85019666488 | |
dc.description.abstract | Background: To evaluate HIV infection-induced alterations in the oral mucosa by comparing inflammation, cell maturation, and cytomorphometric changes in oral mucosal cells between HIV-infected patients undergoing highly active antiretroviral therapy (HAART) and non-HIV-infected patients. Methods: Thirty HIV-infected patients undergoing HAART and 30 non-HIV-infected patients were studied. Four smears were obtained from the lateral border of the tongue and floor of the mouth with a cytobrush. One sample was stained by the Papanicolaou technique, and three samples were processed for Feulgen staining. Papanicolaou-stained smears were analyzed by light microscopy, and the cytoplasmic (CA) and nuclear (NA) area were measured with the Software AxioVision 4.7. Results: The Wilcoxon signed-rank test showed a significant difference in intermediate epithelial cell types between the HIV-infected and non-HIV-infected groups (P=.005). However, this difference was not observed for superficial epithelial cell types with (P=.672) and without a nucleus (P=.069). Comparative analysis revealed no significant difference in CA (P=.604), NA (P=.298) or NA/CA (P=.456) between the HIV-infected and non-HIV-infected groups. Keratohyalin granules were more frequent in the non-HIV-infected group (P=.0001). Conclusions: The results showed alterations in cell maturation in HIV-infected patients undergoing HAART with undetectable viral load, but no morphometric changes were observed. | |
dc.language | eng | |
dc.relation | Journal of Oral Pathology and Medicine | |
dc.relation | 0,791 | |
dc.relation | 0,791 | |
dc.rights | Acesso restrito | |
dc.source | Scopus | |
dc.subject | highly active antiretroviral therapy | |
dc.subject | HIV infection | |
dc.subject | oral cytology | |
dc.subject | oral pathology | |
dc.title | Cytological and cytomorphometric evaluation of the oral mucosa in HIV-infected patients undergoing antiretroviral therapy | |
dc.type | Artículos de revistas | |