Oxidative stress in hoof laminar tissue of horses with lethal gastrointestinal diseases

dc.contributorFederal University of Paraná (Curitiba campus)
dc.contributorUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2018-12-11T17:27:21Z
dc.date.available2018-12-11T17:27:21Z
dc.date.created2018-12-11T17:27:21Z
dc.date.issued2016-03-01
dc.identifierVeterinary Immunology and Immunopathology, v. 171, p. 66-72.
dc.identifier1873-2534
dc.identifier0165-2427
dc.identifierhttp://hdl.handle.net/11449/177834
dc.identifier10.1016/j.vetimm.2016.02.008
dc.identifier2-s2.0-84959019036
dc.identifier2-s2.0-84959019036.pdf
dc.description.abstractTissue damage caused by oxidative stress is involved in the pathogenesis of several diseases in animals and man, and is believed to play a role in the development of laminitis in horses. The aim of this study was to investigate the oxidative stress associated with laminar lesions in horses with lethal gastrointestinal disorders. Laminar tissue samples of the hoof of 30 horses were used. Tissue samples were divided as follows: six healthy horses (control group-CG), and 24 horses that died after complications of gastrointestinal diseases (group suffering from gastrointestinal disorders-GDG). Superoxide dismutase (SOD2) and nitrotyrosine immunostaining and the severity of laminar lesions were evaluated. Presence of laminar lesions and immunostaining for nitrotyrosine and SOD2 were only evident in horses from the GDG group. Thus, oxidative stress may play a role in the pathogenesis of laminar lesions secondary to gastrointestinal disorders.
dc.languageeng
dc.relationVeterinary Immunology and Immunopathology
dc.relation0,680
dc.rightsAcesso aberto
dc.sourceScopus
dc.subjectEquine
dc.subjectImmunohistochemistry
dc.subjectLaminitis
dc.subjectNitrotyrosine
dc.subjectSuperoxide dismutase
dc.titleOxidative stress in hoof laminar tissue of horses with lethal gastrointestinal diseases
dc.typeArtículos de revistas


Este ítem pertenece a la siguiente institución