dc.contributorUniversidade Estadual Paulista (Unesp)
dc.contributorHospital Dr. Amaral Carvalho
dc.contributorSannio University
dc.date.accessioned2018-12-11T17:22:43Z
dc.date.available2018-12-11T17:22:43Z
dc.date.created2018-12-11T17:22:43Z
dc.date.issued2018-01-01
dc.identifierLeukemia and Lymphoma.
dc.identifier1029-2403
dc.identifier1042-8194
dc.identifierhttp://hdl.handle.net/11449/176842
dc.identifier10.1080/10428194.2018.1499905
dc.identifier2-s2.0-85053345241
dc.identifier4132731111630799
dc.description.abstractChronic myeloid leukemia (CML) is a stem cell derived malignant disorder result of translocation t(9;22)(q34;q11) called Philadelphia chromosome (Ph+). microRNAS (miRNAs) are involved in several biological processes, altering the progression of various pathologies, including CML. This study evaluated whether circulating miRNAs display differential expression profiles in peripheral blood of CML-Chronic Phase (CML-CP) patients newly diagnosed in comparison with CML-CP treated with imatinib. We obtained peripheral blood samples from CML-CP Ph+ patients divided among group 1 (untreated newly diagnosed) and group 2 (treated with imatinib). A pool of total leukocytes from healthy donors was considered as control group. Expression analyses were performed for 768 miRNAs by RT-qPCR array. Bioinformatic tools were used to identify significant pathways and interaction networks. We found 80 deregulated miRNAs between the groups and, according to bioinformatic analysis, they are involved in different pathways, including molecular mechanisms of cancer. The study allows better understanding of disease molecular behavior, and it is useful for possible monitoring CML treatment and prognostic biomarkers identification.
dc.languageeng
dc.relationLeukemia and Lymphoma
dc.relation0,976
dc.relation0,976
dc.rightsAcesso aberto
dc.sourceScopus
dc.subjectBiomarkers
dc.subjectchronic phase
dc.subjectgene expression regulation
dc.subjectimatinib mesylate
dc.subjectleukemia
dc.subjectmicroRNAs
dc.subjectmyeloid
dc.subjectPhiladelphia chromosome
dc.titleCirculating microRNAs expression profile in newly diagnosed and imatinib treated chronic phase–chronic myeloid leukemia
dc.typeArtículos de revistas


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