dc.contributor | Universidade Estadual Paulista (Unesp) | |
dc.date.accessioned | 2018-12-11T17:19:48Z | |
dc.date.available | 2018-12-11T17:19:48Z | |
dc.date.created | 2018-12-11T17:19:48Z | |
dc.date.issued | 2018-06-01 | |
dc.identifier | Respiratory Medicine, v. 139, p. 34-38. | |
dc.identifier | 1532-3064 | |
dc.identifier | 0954-6111 | |
dc.identifier | http://hdl.handle.net/11449/176255 | |
dc.identifier | 10.1016/j.rmed.2018.04.012 | |
dc.identifier | 2-s2.0-85046356221 | |
dc.identifier | 2-s2.0-85046356221.pdf | |
dc.description.abstract | Objective: To investigate the relationship between Vitamin D and exacerbation in COPD patients. Methods: The PubMed database was searched for articles published from 2012 onwards using search terms related to Vitamin D and exacerbation in COPD patients. Meta-analysis, clinical trials, observational studies, and human studies were included. Non-English articles or articles with full text unavailable were excluded; a total of 15 articles were selected. Results: The association between exacerbation frequency and Vitamin D levels in observational studies remains controversial, however, meta-analysis revealed a negative association between serum Vitamin D and exacerbation. Also, two clinical trials showed that Vitamin D3 supplementation in COPD patients reduced the risk of moderate and severe exacerbation. Vitamin D binding protein (VDBP) polymorphisms seem to affect patient exacerbation susceptibility. Conclusions: Few studies in literature have data related to diet, 25-hydroxyVitamin D [25(OH)D] and polymorphism in COPD exacerbation. One clinical trial indicates Vitamin D supplementation plays a role in COPD patients with hypovitaminosis D in preventing exacerbations. Further studies are needed to elucidate the role of Vitamin D in this population and to establish the best marker for Vitamin D, which patient subgroups will benefit, and the best supplement dosage without leading to toxicity. | |
dc.language | eng | |
dc.relation | Respiratory Medicine | |
dc.relation | 1,472 | |
dc.rights | Acesso aberto | |
dc.source | Scopus | |
dc.subject | Chronic obstructive pulmonary disease | |
dc.subject | Exacerbation | |
dc.subject | Polymorphisms | |
dc.subject | Supplementation | |
dc.subject | Vitamin D | |
dc.title | The relationship between Vitamin D status and exacerbation in COPD patients– a literature review | |
dc.type | Otros | |