Artículos de revistas
A PLAG1 mutation contributed to stature recovery in modern cattle
Fecha
2017-12-01Registro en:
Scientific Reports, v. 7, n. 1, 2017.
2045-2322
10.1038/s41598-017-17127-1
2-s2.0-85038072820
2-s2.0-85038072820.pdf
0440506054685407
Autor
Universidade Estadual Paulista (Unesp)
Collaborating Centre on Animal Genomics and Bioinformatics
Università Cattolica del Sacro Cuore
Inc.
UFPI - Universidade Federal do Piauí
USDA
Universidade Federal de Goiás (UFG)
GenSys Consultores Associados
Centro Universitário Católico Salesiano
University of Maryland
Società Friulana di Archeologia
Istituto di Genomica Applicata
Università di Udine
Division of Livestock Sciences
Institución
Resumen
The recent evolution of cattle is marked by fluctuations in body size. Height in the Bos taurus lineage was reduced by a factor of ∼1.5 from the Neolithic to the Middle Ages, and increased again only during the Early Modern Ages. Using haplotype analysis, we found evidence that the bovine PLAG1 mutation (Q) with major effects on body size, weight and reproduction is a >1,000 years old derived allele that increased rapidly in frequency in Northwestern European B. taurus between the 16th and 18th centuries. Towards the 19th and 20th centuries, Q was introgressed into non-European B. taurus and Bos indicus breeds. These data implicate a major role of Q in recent changes in body size in modern cattle, and represent one of the first examples of a genomic sweep in livestock that was driven by selection on a complex trait.