Activity of gallic acid and its ester derivatives in Caenorhabditis elegans and zebrafish (Danio rerio) models

dc.contributorUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2018-12-11T17:16:09Z
dc.date.available2018-12-11T17:16:09Z
dc.date.created2018-12-11T17:16:09Z
dc.date.issued2017-10-01
dc.identifierFuture Medicinal Chemistry, v. 9, n. 16, p. 1863-1872, 2017.
dc.identifier1756-8927
dc.identifier1756-8919
dc.identifierhttp://hdl.handle.net/11449/175523
dc.identifier10.4155/fmc-2017-0096
dc.identifier2-s2.0-85034666874
dc.identifier3637285622123132
dc.identifier0992736452764550
dc.identifier0000-0003-2440-8097
dc.description.abstractAim: Gallic acid and its ester derivatives have shown antifungal activity in vitro. This study was performed to investigate their activity against Candida albicans and their toxicity in the animal models Caenorhabditis elegans and zebrafish embryos. Results: The compounds protected worms from C. albicans infection. The dodecyl gallate was the most effective. In zebrafish embryo, gallic acid and dodecyl gallate were the least toxic. Conclusion: Gallic acid and its ester derivatives have potential for in vivo use against C. albicans infection. The antifungal effects and toxicity of gallate esters in these alternative animal models were dependent on carbon chain length.
dc.languageeng
dc.relationFuture Medicinal Chemistry
dc.relation1,111
dc.relation1,111
dc.rightsAcesso restrito
dc.sourceScopus
dc.subjectalternative animal models
dc.subjectantifungal development
dc.subjectgallates
dc.subjectgallic acid
dc.subjectinfection
dc.titleActivity of gallic acid and its ester derivatives in Caenorhabditis elegans and zebrafish (Danio rerio) models
dc.typeArtículos de revistas


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