Brasil | Artículos de revistas
dc.contributorUniversidade Estadual Paulista (Unesp)
dc.contributorUniversidade de São Paulo (USP)
dc.contributorBinderware Biomaterials Ltda
dc.contributorUniversidade Federal de Santa Catarina (UFSC)
dc.date.accessioned2018-12-11T17:13:49Z
dc.date.available2018-12-11T17:13:49Z
dc.date.created2018-12-11T17:13:49Z
dc.date.issued2017-08-02
dc.identifierBrazilian Dental Journal, v. 28, n. 3, p. 287-295, 2017.
dc.identifier1806-4760
dc.identifier0103-6440
dc.identifierhttp://hdl.handle.net/11449/175005
dc.identifier10.1590/0103-6440201601454
dc.identifierS0103-64402017000300287
dc.identifier2-s2.0-85026828838
dc.identifierS0103-64402017000300287.pdf
dc.description.abstractInnovative biomaterials can provide a promising new direction for the treatment of bone defects, stimulating a proper repair process, with no damage to adjacent tissues. The purpose of this in vivo study was to evaluate the biocompatibility and the osteoinductive capacity of chitosan-collagen biomembrane and scaffold containing calcium aluminate cement. Eighteen New Zealand white rabbits (Oryctolagus cuniculus) were distributed according to the experimental times of analysis (7, 15 and 30 days). Four bone defects were created in the rabbits calvaria, which were individually filled with the biomembrane, scaffold, blood clot (negative control) and autologous bone (positive control). Histopathological analysis was performed using optical microscope at 32×, 64×, 125× and 320× magnifications. Cell response to inflammation and new bone tissue formation was quantified using a score system. The biomembrane group presented greater inflammatory response at 15 days, with significant difference to autologous bone group (p<0.05). There was no statistically significant difference for foreign body type reaction among groups (p>0.05). Concerning new bone formation, linear closure of the defect area was observed more evidently in the group with autologous bone. The scaffold group presented similar results compared with the autologous bone group at 30 days (p>0.05). Both tested biomaterials presented similar biocompatibility compared with the control groups. In addition, the biomembrane and scaffold presented similar osteoinductive capacity, stimulating bone repair process in the course of the experimental time intervals.
dc.languageeng
dc.relationBrazilian Dental Journal
dc.relation0,476
dc.rightsAcesso aberto
dc.sourceScopus
dc.subjectBiocompatible materials
dc.subjectBone regeneration
dc.subjectCalcium aluminate cement
dc.subjectInflammation
dc.titleRepair of bone defects with chitosan-collagen biomembrane and scaffold containing calcium aluminate cement
dc.typeArtículos de revistas


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