Synthesis, antifungal activity of caffeic acid derivative esters, and their synergism with fluconazole and nystatin against Candida spp.

dc.contributorUniversidade Estadual Paulista (Unesp)
dc.contributorUniversidade Estadual de Campinas (UNICAMP)
dc.contributorLetters and Exact Sciences
dc.date.accessioned2018-12-11T17:07:27Z
dc.date.available2018-12-11T17:07:27Z
dc.date.created2018-12-11T17:07:27Z
dc.date.issued2016-12-01
dc.identifierDiagnostic Microbiology and Infectious Disease, v. 86, n. 4, p. 387-391, 2016.
dc.identifier1879-0070
dc.identifier0732-8893
dc.identifierhttp://hdl.handle.net/11449/173724
dc.identifier10.1016/j.diagmicrobio.2016.08.002
dc.identifier2-s2.0-84994234378
dc.identifier2-s2.0-84994234378.pdf
dc.identifier0992736452764550
dc.description.abstractWe tested the antifungal potential of caffeic acid and 8 of its derivative esters against Candidaalbicans ATCC 90028 and 9 clinical isolatesand carried out a synergism assay with fluconazole and nystatin. Propyl caffeate (C3) showed the best antifungal activity against the tested strains. When in combination, C3 markedly reduced the MIC of fluconazole and nystatin with synergistic effect up to 64-fold. Finally, C3 showed a high IC50 value and selective indexagainst oral keratinocytes, demonstrating low toxicity against this cell type and selectivity for yeast cells. Further research should confirm its antifungal potential for development of combined therapy to treat C. albicans infections.
dc.languageeng
dc.relationDiagnostic Microbiology and Infectious Disease
dc.relation1,157
dc.rightsAcesso aberto
dc.sourceScopus
dc.subjectAntifungal
dc.subjectCaffeic acid
dc.subjectCandida albicans
dc.subjectSynergism
dc.titleSynthesis, antifungal activity of caffeic acid derivative esters, and their synergism with fluconazole and nystatin against Candida spp.
dc.typeArtículos de revistas


Este ítem pertenece a la siguiente institución