dc.contributorUniversidade Federal de São Carlos (UFSCar)
dc.contributorUniversidade Estadual Paulista (Unesp)
dc.contributorNeuroscience and Behavioral Institute-IneC
dc.date.accessioned2018-12-11T16:52:40Z
dc.date.available2018-12-11T16:52:40Z
dc.date.created2018-12-11T16:52:40Z
dc.date.issued2018-06-01
dc.identifierNeuropharmacology, v. 135, p. 376-385.
dc.identifier1873-7064
dc.identifier0028-3908
dc.identifierhttp://hdl.handle.net/11449/170848
dc.identifier10.1016/j.neuropharm.2018.03.008
dc.identifier2-s2.0-85044634255
dc.identifier2-s2.0-85044634255.pdf
dc.description.abstractIt is well-known that the exposure of rodents to threatening environments [e.g., the open arm of the elevated-plus maze (EPM)] elicits pain inhibition. Systemic and/or intracerebral [e.g., periaqueductal gray matter, amygdala) injections of antiaversive drugs [e.g., serotonin (5-HT) ligands, selective serotonin reuptake inhibitors (SSRIs)] have been used to change EPM-open arm confinement induced antinociception (OAA). Here, we investigated (i) the role of the 5-HT1A and 5-HT2C receptors located in the amygdaloid complex on OAA as well as (ii) the effects of systemic pretreatment with fluoxetine (an SSRI) on the effects of intra-amygdala injections of 8-OH-DPAT (a 5-HT1A agonist) or MK-212 (a 5-HT2C agonist) on nociception in mice confined to the open arm or enclosed arm of the EPM. Nociception was assessed by the writhing test. Intra-amygdala injections of 8-OH-DPAT (10 nmol) or MK-212 (0.63 nmol) produced a pronociceptive effect and intensified OAA, respectively. Fluoxetine (2.5 mg/kg, intraperitoneally) did not change 8-OH-DPAT effects on nociception but antagonized the enhancement of the OAA produced by MK-212. Interestingly, prior injection of SB 242084 (a selective 5-HT2C antagonist) into the amygdala also blocked the MK-212 effects on OAA. These results indicate that 5-HT may facilitate nociception and intensify OAA, respectively, at 5-HT1A and 5-HT2C receptors located in the amygdala of mice. The impairment produced by systemic fluoxetine on the OAA enhancement provoked by intra-amygdala MK-212 suggests that this type of fear-induced antinociception may be modulated by SSRIs.
dc.languageeng
dc.relationNeuropharmacology
dc.relation2,043
dc.rightsAcesso aberto
dc.sourceScopus
dc.subject5-HT1A and 5-HT2C receptors
dc.subjectAmygdala
dc.subjectAntinociception
dc.subjectElevated plus maze
dc.subjectFluoxetine
dc.subjectMice
dc.titleActivation of 5-HT2C (but not 5-HT1A) receptors in the amygdala enhances fear-induced antinociception: Blockade with local 5-HT2C antagonist or systemic fluoxetine
dc.typeArtículos de revistas


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