dc.contributor | Universidade Federal de São Carlos (UFSCar) | |
dc.contributor | Universidade Estadual Paulista (Unesp) | |
dc.contributor | Neuroscience and Behavioral Institute-IneC | |
dc.date.accessioned | 2018-12-11T16:52:40Z | |
dc.date.available | 2018-12-11T16:52:40Z | |
dc.date.created | 2018-12-11T16:52:40Z | |
dc.date.issued | 2018-06-01 | |
dc.identifier | Neuropharmacology, v. 135, p. 376-385. | |
dc.identifier | 1873-7064 | |
dc.identifier | 0028-3908 | |
dc.identifier | http://hdl.handle.net/11449/170848 | |
dc.identifier | 10.1016/j.neuropharm.2018.03.008 | |
dc.identifier | 2-s2.0-85044634255 | |
dc.identifier | 2-s2.0-85044634255.pdf | |
dc.description.abstract | It is well-known that the exposure of rodents to threatening environments [e.g., the open arm of the elevated-plus maze (EPM)] elicits pain inhibition. Systemic and/or intracerebral [e.g., periaqueductal gray matter, amygdala) injections of antiaversive drugs [e.g., serotonin (5-HT) ligands, selective serotonin reuptake inhibitors (SSRIs)] have been used to change EPM-open arm confinement induced antinociception (OAA). Here, we investigated (i) the role of the 5-HT1A and 5-HT2C receptors located in the amygdaloid complex on OAA as well as (ii) the effects of systemic pretreatment with fluoxetine (an SSRI) on the effects of intra-amygdala injections of 8-OH-DPAT (a 5-HT1A agonist) or MK-212 (a 5-HT2C agonist) on nociception in mice confined to the open arm or enclosed arm of the EPM. Nociception was assessed by the writhing test. Intra-amygdala injections of 8-OH-DPAT (10 nmol) or MK-212 (0.63 nmol) produced a pronociceptive effect and intensified OAA, respectively. Fluoxetine (2.5 mg/kg, intraperitoneally) did not change 8-OH-DPAT effects on nociception but antagonized the enhancement of the OAA produced by MK-212. Interestingly, prior injection of SB 242084 (a selective 5-HT2C antagonist) into the amygdala also blocked the MK-212 effects on OAA. These results indicate that 5-HT may facilitate nociception and intensify OAA, respectively, at 5-HT1A and 5-HT2C receptors located in the amygdala of mice. The impairment produced by systemic fluoxetine on the OAA enhancement provoked by intra-amygdala MK-212 suggests that this type of fear-induced antinociception may be modulated by SSRIs. | |
dc.language | eng | |
dc.relation | Neuropharmacology | |
dc.relation | 2,043 | |
dc.rights | Acesso aberto | |
dc.source | Scopus | |
dc.subject | 5-HT1A and 5-HT2C receptors | |
dc.subject | Amygdala | |
dc.subject | Antinociception | |
dc.subject | Elevated plus maze | |
dc.subject | Fluoxetine | |
dc.subject | Mice | |
dc.title | Activation of 5-HT2C (but not 5-HT1A) receptors in the amygdala enhances fear-induced antinociception: Blockade with local 5-HT2C antagonist or systemic fluoxetine | |
dc.type | Artículos de revistas | |