Artículos de revistas
Early Empiric Antibiotic Use Is Associated with Delayed Feeding Tolerance in Preterm Infants: A Retrospective Analysis
Fecha
2017-07-01Registro en:
Journal of Pediatric Gastroenterology and Nutrition, v. 65, n. 1, p. 107-110, 2017.
1536-4801
0277-2116
10.1097/MPG.0000000000001490
2-s2.0-85021807051
Autor
Universidade de São Paulo (USP)
Universidade Federal de São Paulo (UNIFESP)
Instituto de Medicina Integral Prof Fernando Figueira-IMIP
Hospital Universitário da Universidade Federal Do Maranhão
Universidade Estadual de Campinas (UNICAMP)
Universidade Estadual Paulista (Unesp)
Instituto Fernandes Figueira-FIOCRUZ
Faculdade de Medicina da PUC Porto Alegre
Universidade Federal Do Rio Grande Do sul
Universidade Estadual Do Rio de Janeiro
Universidade Federal de Minas Gerais (UFMG)
Universidade Federal de Uberlândia (UFU)
Faculdade de Ciências Médicas de Minas Gerais
Hospital Estadual Sumaré
Hospital Geral de Pirajussara
Hospital Estadual de Diadema
Universidade Estadual de Londrina (UEL)
Universidade Federal do Paraná (UFPR)
University of Toronto
Institución
Resumen
The causative factors of neonatal feeding intolerance are poorly understood, but potentially related to clinical practices such as empiric antibiotic usage. The objective of this study was to evaluate whether early empiric antibiotic exposure negatively affects preterm infants' enteral feeding tolerance. Data from infants without risk factors for sepsis, 500 to 1499 g birth weight and 24 to 34 weeks gestational age were analyzed. The primary outcomes were the empiric antibiotic exposure effects on the infants' total parenteral nutrition usage duration and prevalence of necrotizing enterocolitis (NEC). Among the 901 infants included, 67 were exposed to early empiric antibiotic. A 50% increase in parenteral nutrition usage duration and a 4-fold greater prevalence of NEC was seen in the early empiric antibiotic-exposed neonates, when compared with control infants (P<0.01). Early empiric antibiotic exposure appears to negatively influence preterm infant feeding tolerance and possibly contributes to NEC.