The prodrug approach: A successful tool for improving drug solubility

dc.contributorUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2018-12-11T16:44:51Z
dc.date.available2018-12-11T16:44:51Z
dc.date.created2018-12-11T16:44:51Z
dc.date.issued2016-01-01
dc.identifierMolecules, v. 21, n. 1, 2016.
dc.identifier1420-3049
dc.identifierhttp://hdl.handle.net/11449/169189
dc.identifier10.3390/molecules21010042
dc.identifier2-s2.0-85000542430
dc.identifier2-s2.0-85000542430.pdf
dc.identifier9734333607975413
dc.identifier0000-0003-4141-0455
dc.description.abstractProdrug design is a widely known molecular modification strategy that aims to optimize the physicochemical and pharmacological properties of drugs to improve their solubility and pharmacokinetic features and decrease their toxicity. A lack of solubility is one of the main obstacles to drug development. This review aims to describe recent advances in the improvement of solubility via the prodrug approach. The main chemical carriers and examples of successful strategies will be discussed, highlighting the advances of this field in the last ten years.
dc.languageeng
dc.relationMolecules
dc.relation0,855
dc.rightsAcesso aberto
dc.sourceScopus
dc.subjectMolecular modification
dc.subjectProdrug
dc.subjectSolubility
dc.subjectSolubility of prodrugs
dc.subjectWater-soluble prodrugs
dc.titleThe prodrug approach: A successful tool for improving drug solubility
dc.typeOtros


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