Synthesis of the peptide Ac-Wahx-KTTKS and evaluation of the ability to induce in vitro collagen synthesis

dc.contributorUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2018-12-11T16:42:45Z
dc.date.available2018-12-11T16:42:45Z
dc.date.created2018-12-11T16:42:45Z
dc.date.issued2016-06-01
dc.identifierProtein and Peptide Letters, v. 23, n. 6, p. 544-547, 2016.
dc.identifier1875-5305
dc.identifier0929-8665
dc.identifierhttp://hdl.handle.net/11449/168728
dc.identifier2-s2.0-84974735668
dc.description.abstractIn this work, we report the synthesis of a peptide analogue of the KTTKS, termed Ac-Wahx-KTTKS and evaluate its cytotoxicity and role in biosynthesis of collagen for future application in skin aging. The peptide was obtained with purity higher than 97.5%. In the cytotoxicity assay, we observed non-toxic effects for Ac-WAhx-KTTKS at concentrations below 600 ôM for HaCaT and 500 ôM for HepG2 cells, respectively. After 24 and 48 h it was possible to observe significant changes in collagen synthesis in the groups treated with various concentrations of the peptide. In conclusion, the Ac-Wahx-KTTKS peptide increased collagen synthesis in fibroblasts by 80% and it is a promising candidate for improving skin aging.
dc.languageeng
dc.relationProtein and Peptide Letters
dc.relation0,429
dc.rightsAcesso restrito
dc.sourceScopus
dc.subjectAc-WAhx-KTTKS
dc.subjectAntiaging
dc.subjectCollagen biosynthesis
dc.subjectCytotoxicity
dc.subjectPeptide synthesis
dc.subjectSkin functions.
dc.titleSynthesis of the peptide Ac-Wahx-KTTKS and evaluation of the ability to induce in vitro collagen synthesis
dc.typeArtículos de revistas


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