Cell growth on 3D microstructured surfaces

dc.contributorUniversidade de São Paulo (USP)
dc.contributorFederal University of Ouro Preto
dc.contributorUniversidade Estadual Paulista (Unesp)
dc.contributorLawrence Berkeley National Laboratory
dc.date.accessioned2018-12-11T16:41:43Z
dc.date.available2018-12-11T16:41:43Z
dc.date.created2018-12-11T16:41:43Z
dc.date.issued2016-06-01
dc.identifierMaterials Science and Engineering C, v. 63, p. 686-689.
dc.identifier0928-4931
dc.identifierhttp://hdl.handle.net/11449/168546
dc.identifier10.1016/j.msec.2016.03.026
dc.identifier2-s2.0-84962667239
dc.identifier2-s2.0-84962667239.pdf
dc.description.abstractChinese Hamster Ovary (CHO) cell cultures were grown on surfaces lithographed with periodic 3D hexagonal microcavity array morphology. The range of microcavity size (inscribed circle diameter) was from 12 μm to 560 μm. CHO cells were grown also on flat surfaces. The characterization was performed with respect to cell growth density (number of nuclei per unit area) by fluorescence optical microscopy and evaluated by correlation function analysis. We found that optimum microcavity radius was 80 μm, concerning to the maximum cell growth density, being even greater than the growth density on a flat (unstructured) substrate of the same material. This finding can be important for optimization of biotechnological processes and devices.
dc.languageeng
dc.relationMaterials Science and Engineering C
dc.relation1,110
dc.rightsAcesso aberto
dc.sourceScopus
dc.subjectBiomaterials
dc.subjectCell aggregation
dc.subjectOptical microscopy
dc.subjectSurface patterning
dc.titleCell growth on 3D microstructured surfaces
dc.typeArtículos de revistas


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