dc.contributor | Universidade Veiga de Almeida | |
dc.contributor | Universidade Federal Fluminense (UFF) | |
dc.contributor | Universidade de São Paulo (USP) | |
dc.contributor | Universidade Estadual Paulista (Unesp) | |
dc.contributor | INMETRO – Instituto Nacional de Metrologia Qualidade e Tecnologia | |
dc.date.accessioned | 2018-12-11T16:40:38Z | |
dc.date.available | 2018-12-11T16:40:38Z | |
dc.date.created | 2018-12-11T16:40:38Z | |
dc.date.issued | 2015-11-01 | |
dc.identifier | Brazilian Dental Journal, v. 26, n. 6, p. 561-565, 2015. | |
dc.identifier | 1806-4760 | |
dc.identifier | 0103-6440 | |
dc.identifier | http://hdl.handle.net/11449/168292 | |
dc.identifier | 10.1590/0103-6440201300394 | |
dc.identifier | S0103-64402015000600561 | |
dc.identifier | 2-s2.0-84954071804 | |
dc.identifier | S0103-64402015000600561.pdf | |
dc.description.abstract | The aim of this study was to evaluate the association of the polymorphisms in TCN2 (rs1801198) gene and in MTRR (rs1801394) gene with nonsyndromic cleft lip and/or palate (NSCL/P) in a Brazilian population. Genomic DNA was extracted from buccal cells. The polymorphisms in TCN2 (rs1801198) and MTRR (rs1801394) genes were genotyped by carrying out real-time PCR and Taqman assay. Chi-square test was used to determine the association between genotype and allele frequencies with NSCL/P and NSCL/P subgroups (cleft lip only, cleft lip and palate, and cleft palate only). Eight hundred and sixty seven unrelated individuals (401 cases with NSCL/P and 466 individuals without cleft) were evaluated. Genotype distributions of TCN2 and MTRR polymorphisms were in Hardy-Weinberg equilibrium. The TCN2 polymorphic genotype GG was identified in 16.7% of the NSCL/P group and in 14.1% of the non-cleft group (p>0.05). Similarly, the frequency of MTRR genotype (GG) was similar in NSCL/P group (15.5%) and control group (17.8%) (p>0.05). Multivariate analysis showed an association between MTRR and the subgroup that the mother smoked during pregnancy (p=0.039). Our findings did not demonstrate an association between TCN2 polymorphisms and NSCL/P, however suggests an association between MTRR and NSCL/P etiology. | |
dc.language | eng | |
dc.relation | Brazilian Dental Journal | |
dc.relation | 0,476 | |
dc.rights | Acesso aberto | |
dc.source | Scopus | |
dc.subject | Cleft lip and/or palate | |
dc.subject | Folic acid | |
dc.subject | Genetic polymorphisms | |
dc.subject | MTRR gene | |
dc.subject | Subphenotypes | |
dc.subject | TCN2 gene | |
dc.subject | Vitamin B12 | |
dc.title | Genetic variants in folate and cobalamin metabolism-related genes in nonsyndromic cleft lip and/or Palate | |
dc.type | Artículos de revistas | |