Potential application of rLc36 protein for diagnosis of canine visceral leishmaniasis

dc.contributorUniversidade Estadual Paulista (Unesp)
dc.contributorUniversidade de São Paulo (USP)
dc.contributorUniversidade Federal de São Carlos (UFSCar)
dc.date.accessioned2018-11-29T06:59:19Z
dc.date.available2018-11-29T06:59:19Z
dc.date.created2018-11-29T06:59:19Z
dc.date.issued2018-03-01
dc.identifierMemorias Do Instituto Oswaldo Cruz. Rio De Janeiro, Rj: Fundaco Oswaldo Cruz, v. 113, n. 3, p. 197-201, 2018.
dc.identifier0074-0276
dc.identifierhttp://hdl.handle.net/11449/165997
dc.identifier10.1590/0074-02760170171
dc.identifierS0074-02762018000300197
dc.identifierWOS:000424492000008
dc.identifierS0074-02762018000300197.pdf
dc.identifier6720223715917381
dc.identifier0000-0002-3350-8308
dc.description.abstractVisceral leishmaniasis (VL) is fatal if left untreated. Infected dogs are important reservoirs of the disease, and thus specific identification of infected animals is very important. Several diagnostic tests have been developed for canine VL (CVL); however, these tests show varied specificity and sensitivity. The present study describes the recombinant protein rLc36, expressed by Leishmania infantum, as potential antigen for more sensitive and specific diagnosis of CVL based on an immunoenzymatic assay. The concentration of 1.0 mu g/mL of rLc36 enabled differentiation of positive and negative sera and showed a sensitivity of 85% and specificity of 71% (with 95% confidence), with an accuracy of 76%.
dc.languageeng
dc.publisherFundaco Oswaldo Cruz
dc.relationMemorias Do Instituto Oswaldo Cruz
dc.rightsAcesso aberto
dc.sourceWeb of Science
dc.subjectcanine visceral leishmaniasis
dc.subjectimmunodiagnosis
dc.subjectrecombinant protein
dc.titlePotential application of rLc36 protein for diagnosis of canine visceral leishmaniasis
dc.typeArtículos de revistas


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