Trypanocidal activity of mastoparan from Polybia paulista wasp venom by interaction with TcGAPDH

dc.contributorUniv Fed Ceara
dc.contributorUniversidade Estadual Paulista (Unesp)
dc.contributorUniv Fed Rio Grande do Norte
dc.date.accessioned2018-11-28T21:36:47Z
dc.date.available2018-11-28T21:36:47Z
dc.date.created2018-11-28T21:36:47Z
dc.date.issued2017-10-01
dc.identifierToxicon. Oxford: Pergamon-elsevier Science Ltd, v. 137, p. 168-172, 2017.
dc.identifier0041-0101
dc.identifierhttp://hdl.handle.net/11449/165808
dc.identifier10.1016/j.toxicon.2017.08.002
dc.identifierWOS:000411542300025
dc.identifierWOS000411542300025.pdf
dc.identifier2901888624506535
dc.description.abstractChagas disease, considered a neglected disease, is a parasitic infection caused by Trypanosoma cruzi, which is endemic throughout the world. Previously, the antimicrobial effect of Mastoparan (MP) from Polybia paulista wasp venom against bacteria was described. To continue the study, we report in this short communication the antimicrobial effect of MP against Trypanosoma cruzi. MP inhibits all T. cruzi developmental forms through the inhibition of TcGAPDH suggested by the molecular docking. In conclusion, we suggest there is an antimicrobial effect also on T. cruzi. (C) 2017 Elsevier Ltd. All rights reserved.
dc.languageeng
dc.publisherElsevier B.V.
dc.relationToxicon
dc.relation0,692
dc.rightsAcesso aberto
dc.sourceWeb of Science
dc.subjectAntiparasitic agents
dc.subjectMolecular docking
dc.subjectWasp venom
dc.subjectMastoparan
dc.titleTrypanocidal activity of mastoparan from Polybia paulista wasp venom by interaction with TcGAPDH
dc.typeArtículos de revistas


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