dc.contributorUniv Montreal
dc.contributorUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2018-11-27T13:25:51Z
dc.date.available2018-11-27T13:25:51Z
dc.date.created2018-11-27T13:25:51Z
dc.date.issued2016-05-01
dc.identifierAnimal Reproduction Science. Amsterdam: Elsevier Science Bv, v. 168, p. 34-39, 2016.
dc.identifier0378-4320
dc.identifierhttp://hdl.handle.net/11449/165146
dc.identifier10.1016/j.anireprosci.2016.02.023
dc.identifierWOS:000374914200005
dc.identifierWOS000374914200005.pdf
dc.description.abstractIn the ovary, angiotensin II (ANGII) acts through the type 2 receptor (AGTR2) to induce ovulation and may play a role in follicle atresia. In this study, we determined the expression of AGTR2 mRNA and protein during follicle formation in the bovine ovary. Female fetuses at different gestational ages (60, 75, 90, 120, 150 and 210 days) were used for immunolocalization of AGTR2. At day 60, AGTR2 was localized to the cytoplasm of oogonia; from days 75 to 150, during follicle formation and development to secondary stage, AGTR2 immunostaining was weak and irregular, but from day 210 staining became evident in granulosa cells of preantral follicles and in both granulosa and theca cells of small antral follicles. These data differ from those in pigs, in which AGTR2 protein is detected in preantral follicles throughout gestation. Abundance of AGTR2 mRNA in whole ovaries did not change with fetal age. In conclusion, AGTR2 protein is expressed in ovigerous cords in fetal bovine ovaries but not in preantal follicles until the formation of antral follicles. These data suggest important species-specific differences in the expression of AGTR2 in fetal ovaries from polypvulatory and monovulatory animals. (C) 2016 Elsevier B.V. All rights reserved.
dc.languageeng
dc.publisherElsevier B.V.
dc.relationAnimal Reproduction Science
dc.relation0,704
dc.rightsAcesso aberto
dc.sourceWeb of Science
dc.subjectPreantral follicle
dc.subjectAT2
dc.subjectAngiotensin
dc.subjectOvigerous chord
dc.subjectFetal ovary
dc.titleLocalization of angiotensin receptor type 2 in fetal bovine ovaries
dc.typeArtículos de revistas


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