dc.contributorUniversidade Federal de São Carlos (UFSCar)
dc.contributorUniv Fed Rio Grande do Sul
dc.contributorUniversidade Estadual Paulista (Unesp)
dc.contributorInst Pesquisa Celulas Tronco
dc.contributorCtr Res Technol & Educ Vitreous Mat CeRTEV
dc.date.accessioned2018-11-26T17:39:44Z
dc.date.available2018-11-26T17:39:44Z
dc.date.created2018-11-26T17:39:44Z
dc.date.issued2017-07-01
dc.identifierMaterials Science & Engineering C-materials For Biological Applications. Amsterdam: Elsevier Science Bv, v. 76, p. 233-241, 2017.
dc.identifier0928-4931
dc.identifierhttp://hdl.handle.net/11449/163004
dc.identifier10.1016/j.msec.2017.03.056
dc.identifierWOS:000405541600029
dc.identifierWOS000405541600029.pdf
dc.description.abstractIn this study, an evaluation was performed to determine the in vitro bioactivity, viability of stem cells, and antibiofilm effect against Streptococcus mutans of two bioactive gel-glass 60SiO(2)-36CaO-4P(2)O(5) (BG-A) and 80SiO(2)-15CaO-5P(2)O(5) (BG-B) compositions. Both materials were bioactive and undergo the formation of hydroxycarbonate apatite (HCA) on their surfaces when immersed in simulated body fluid (SBF) after 12 h, but the BG-A composition showed a more significant formation rate. The pH variation of the samples during the test in SBF indicated that an abrupt change had occurred for the BG-A composition within the first few hours, and the pH was subsequently maintained over time, supporting its stronger antibacterial effects against S. mutans. For the in vitro viability test using mesenchymal stem cells (MSCs), the BG-B showed significantly higher cell viability compared to the BG-A composition at concentrations of 0.125, 1.25 and 12.50 mg/mL for 2 days. These results indicated that the higher solubility of the BG-A glass favors bioactivity and antibacterial effects. However, as a result of rapid degradation, the increase in the concentration of ions in the cell culture medium was not favorable for cell proliferation. Thus, by varying the composition of glasses, and consequently their dissolution rate, it is possible to favor bioactivity, antimicrobial activity or stem cell proliferation for a particular application of interest. (C) 2017 Elsevier B.V. All rights reserved.
dc.languageeng
dc.publisherElsevier B.V.
dc.relationMaterials Science & Engineering C-materials For Biological Applications
dc.relation1,110
dc.rightsAcesso aberto
dc.sourceWeb of Science
dc.subjectBioactive glass
dc.subjectSol-gel
dc.subjectIn vitro bioactivity
dc.subjectCell viability
dc.subjectStem cells
dc.subjectBiofilm
dc.titleBioactive gel-glasses with distinctly different compositions: Bioactivity, viability of stem cells and antibiofilm effect against Streptococcus mutans
dc.typeArtículos de revistas


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