Platelet-derived growth factor A mRNA in platelets is associated with the degree of hepatic fibrosis in chronic hepatitis C

dc.contributorUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2018-11-26T17:21:00Z
dc.date.available2018-11-26T17:21:00Z
dc.date.created2018-11-26T17:21:00Z
dc.date.issued2017-01-01
dc.identifierRevista Da Sociedade Brasileira De Medicina Tropical. Brasilia: Soc Brasileira Medicina Tropical, v. 50, n. 1, p. 113-116, 2017.
dc.identifier0037-8682
dc.identifierhttp://hdl.handle.net/11449/162579
dc.identifier10.1590/0037-8682-0302-2016
dc.identifierS0037-86822017000100113
dc.identifierWOS:000396497600018
dc.identifierS0037-86822017000100113.pdf
dc.identifier3587895085226224
dc.identifier0000-0001-9200-5391
dc.description.abstractIntroduction: Transforming growth factor beta 1 (TGFB1) and platelet-derived growth factor (PDGF) are the main cytokines related to hepatic fibrogenesis. Methods: RNA isolated from the platelets and hepatic tissue of 43 HCV carriers was used for quantitative polymerase chain reaction to determine TGFB1, PDGFA, and PDGFB RNA expression. Results: The mRNA expression of PDGFA in platelets was significantly lower in the group with advanced fibrosis than in the group with early-stage fibrosis. TGFB1 was more frequently expressed in platelets than in hepatic tissue, which was different from PDGFB. Conclusions: A pathway mediated by overexpression of TGFB1 via PDGFA in megakaryocytes could be involved in the development of fibrosis.
dc.languageeng
dc.publisherSoc Brasileira Medicina Tropical
dc.relationRevista Da Sociedade Brasileira De Medicina Tropical
dc.relation0,658
dc.rightsAcesso aberto
dc.sourceWeb of Science
dc.subjectHepatic fibrosis
dc.subjectPDGF
dc.subjectTGFB
dc.titlePlatelet-derived growth factor A mRNA in platelets is associated with the degree of hepatic fibrosis in chronic hepatitis C
dc.typeArtículos de revistas


Este ítem pertenece a la siguiente institución