Evaluating the efficacies of Maximum Tolerated Dose and metronomic chemotherapies: A mathematical approach

dc.contributorUniversidade Estadual Paulista (Unesp)
dc.contributorUniversidade Federal de Viçosa (UFV)
dc.date.accessioned2018-11-26T16:33:10Z
dc.date.available2018-11-26T16:33:10Z
dc.date.created2018-11-26T16:33:10Z
dc.date.issued2016-08-15
dc.identifierPhysica A-statistical Mechanics And Its Applications. Amsterdam: Elsevier Science Bv, v. 456, p. 145-156, 2016.
dc.identifier0378-4371
dc.identifierhttp://hdl.handle.net/11449/161543
dc.identifier10.1016/j.physa.2016.03.019
dc.identifierWOS:000376693500015
dc.identifierWOS000376693500015.pdf
dc.identifier8232289412108723
dc.identifier0000-0002-2080-8053
dc.description.abstractWe present a mathematical model based on partial differential equations that is applied to understand tumor development and its response to chemotherapy. Our primary aim is to evaluate comparatively the efficacies of two chemotherapeutic protocols, Maximum Tolerated Dose (MTD) and metronomic, as well as two methods of drug delivery. Concerning therapeutic outcomes, the metronomic protocol proves more effective in prolonging the patient's life than MTD. Moreover, a uniform drug delivery method combined with the metronomic protocol is the most efficient strategy to reduce tumor density. (C) 2016 Elsevier B.V. All rights reserved.
dc.languageeng
dc.publisherElsevier B.V.
dc.relationPhysica A-statistical Mechanics And Its Applications
dc.relation0,773
dc.rightsAcesso aberto
dc.sourceWeb of Science
dc.subjectMathematical oncology
dc.subjectCancer
dc.subjectTumor-induced angiogenesis
dc.subjectChemotherapy
dc.titleEvaluating the efficacies of Maximum Tolerated Dose and metronomic chemotherapies: A mathematical approach
dc.typeArtículos de revistas


Este ítem pertenece a la siguiente institución