dc.contributorNunes, Caris Maroni [UNESP]
dc.contributorLima, Valéria Marçal Félix de [UNESP]
dc.contributorUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2016-05-17T16:51:22Z
dc.date.available2016-05-17T16:51:22Z
dc.date.created2016-05-17T16:51:22Z
dc.date.issued2015-08-13
dc.identifierPEREIRA, Dandara Camila Morais. Relação da expressão do tlr-2, da enzima iNOS, das citocinas IL-10, TNF-α e TGF-β com a carga parasitária da pele de cães naturalmente acometidos por leishmaniose visceral: Dandara Camila Morais Pereira. -. 2015. 69 f. Dissertação (mestrado) - Universidade Estadual Paulista Júlio de Mesquita Filho, Faculdade de Medicina Veterinária, 2015.
dc.identifierhttp://hdl.handle.net/11449/138445
dc.identifier000864272
dc.identifier000864272.pdf
dc.identifier33004021075P8
dc.identifier1892359871207408
dc.identifier4875352337860036
dc.description.abstractThe progression of the canine visceral leishmaniasis (CVL) is related to the immune response profile. The effective cellular immunity is related to the predominance of Th1 cytokines such as TNF-α and the disease is related to an exacerbated humoral immune response, with the predominance of Th2 cytokines such as IL-10 and TGF-β. TLR-2 is an important receptor of the innate immunity involved in the induction of the cytokines production and the activation of iNOS in visceral leishmaniasis. To understand how the skin may become a permissive microenvironment for the multiplication of this parasite, the expression of genes encoding to TLR-2, to the iNOS enzyme and to the cytokines IL-10, TNF-α and TGF-β was evaluated in skin of dogs naturally affected by CVL and were then was related to the parasite load of this tissue. We observed that the skin of dogs naturally affected by visceral leishmaniasis has a mixed Th1/Th2 immune response profile, with an increased expression of TLR-2, IL-10 and TNF-α that correlates to the increasing of the parasitic load in this tissue, giving these mediators an important role in the pathogenesis of CVL
dc.languagepor
dc.publisherUniversidade Estadual Paulista (Unesp)
dc.rightsAcesso aberto
dc.sourceAleph
dc.subjectLeishmaniose visceral
dc.subjectCães
dc.subjectCitocinas
dc.subjectExpressão gênica
dc.subjectInterleucina-10
dc.subjectLinfócitos T auxiliares-indutores
dc.subjectFator de crescimento transformador beta
dc.subjectFator de necrose tumoral alfa
dc.subjectReação em cadeia da polimerase
dc.subjectParasitic load
dc.titleRelação da expressão do tlr-2, da enzima iNOS, das citocinas IL-10, TNF-α e TGF-β com a carga parasitária da pele de cães naturalmente acometidos por leishmaniose visceral: Dandara Camila Morais Pereira. -
dc.typeTesis


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