Development and validation of infrared spectroscopy method for the determination of darunavir in tabets

dc.contributorUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2016-01-28T16:56:42Z
dc.date.available2016-01-28T16:56:42Z
dc.date.created2016-01-28T16:56:42Z
dc.date.issued2013
dc.identifierPhysical Chemistry, v. 33, n. 1, p. 1-6, 2013.
dc.identifier2167-7042
dc.identifierhttp://hdl.handle.net/11449/133810
dc.identifier10.5923/j.pc.20130301.01
dc.identifier6638857912920334
dc.identifier9881720291571774
dc.description.abstractDarunavir is a protease inhibitor used in the treatment of HIV infection. It is a pillar of therapy cocktail for patients with this virus. This work proposed the development and validation of an infrared spectroscopy method for the determination of darunavir in tablets. The method was completely validated according to the International Conference on Harmonization guidelines, showing accuracy, precision, selectivity, robustness and linearity. It was linear over the concentration range of 1.5-3.5 mg with correlation coefficients greater than 0.9991 and limits of detection and quantification of 0.12 and 0.36 mg, respectively. The validated method is very useful to the routine quality control of darunavir, since it does not use polluting reagents, it is simple and has low-cost.
dc.languageeng
dc.publisherScientific and Academic Publishing
dc.relationPhysical Chemistry
dc.rightsAcesso restrito
dc.sourceCurrículo Lattes
dc.subjectDarunavir
dc.subjectInfrared
dc.subjectMethod validation
dc.titleDevelopment and validation of infrared spectroscopy method for the determination of darunavir in tabets
dc.typeArtículos de revistas


Este ítem pertenece a la siguiente institución