Spectrophotometric determination of ciprofloxacin hydrochloride in ophthalmic solution

dc.contributorUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2016-01-28T16:56:37Z
dc.date.available2016-01-28T16:56:37Z
dc.date.created2016-01-28T16:56:37Z
dc.date.issued2012
dc.identifierAdvances in Analytical Chemistry, v. 2, n. 6, p. 74-79, 2012.
dc.identifier2163-2847
dc.identifierhttp://hdl.handle.net/11449/133790
dc.identifier10.5923/j.aac.20120206.01
dc.identifier6258455310334944
dc.identifier9881720291571774
dc.description.abstractFrom this study, methods for quantitative analysis were developed to determine cefuroxime sodium in the raw material and in pharmaceutical formulations. These tests included instrumental methods such as spectrophotometry in the ultraviolet, visible and infrared, high performance liquid chromatography and potentiometric determination by microbiological methods (agar diffusion and turbidimetric). The concentration range determined for each method varied greatly, which increases the usability of cefuroxime fori dentifying quality control. In spectrophotometric methods cefuroxime was determined from 5.0μg/ml to 2.0mg/mL.The microbiological methods have determined the drug concentration 30.0-120.0 μg/ml and HPLC ranged from 10.0to15.0μg/ml.The results obtained by analysis of the dosage form were compared to results obtained by analysis of the reference substance and showed significance. These methods proved to be reproducible and rapid determination of cefuroxime can be routinely used in quality control analysis.
dc.languageeng
dc.publisherScientific & Academic Publishing
dc.relationAdvances in Analytical Chemistry
dc.rightsAcesso restrito
dc.sourceCurrículo Lattes
dc.subjectUV spectrophotometry
dc.subjectQuinolones
dc.subjectAnalytical method
dc.subjectCiprofloxacin hydrochloride
dc.titleSpectrophotometric determination of ciprofloxacin hydrochloride in ophthalmic solution
dc.typeArtículos de revistas


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