Stability study and degradation kinetics of ceftazidime in pharmaceutical preparations

dc.contributorUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2016-01-28T16:56:36Z
dc.date.available2016-01-28T16:56:36Z
dc.date.created2016-01-28T16:56:36Z
dc.date.issued2012
dc.identifierAdvances in Analytical Chemistry, v. 2, n. 1, p. 1-5, 2012.
dc.identifier2163-2847
dc.identifierhttp://hdl.handle.net/11449/133787
dc.identifier10.5923/j.aac.20120201.01
dc.identifier9048202968088646
dc.identifier9881720291571774
dc.description.abstractStability study of ceftazidime was realized in order to investigate kinetics of degradation of this drug both in powder for injection and reconstituted sample. Ceftazidime was submitted to conditions of accelerated thermal degradation and photodegradation. Analyses of the degraded samples were performed by microbiological assay and decomposition reactions could be described by zero-order and second-order kinetics. Results obtained confirm the reliability of the microbiological assay for determination of ceftazidime by the presence of its degradation products. The present study revealed thermal and photo lability of the drug, especially as reconstituted sample, and protection is recommended during storage and handling.
dc.languageeng
dc.publisherScientific & Academic Publishing
dc.relationAdvances in Analytical Chemistry
dc.rightsAcesso restrito
dc.sourceCurrículo Lattes
dc.subjectCeftazidime
dc.subjectStability studies
dc.subjectDegradation kinetics
dc.titleStability study and degradation kinetics of ceftazidime in pharmaceutical preparations
dc.typeArtículos de revistas


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