dc.contributor | Universidade Estadual Paulista (Unesp) | |
dc.contributor | Universidade Federal de Santa Maria (UFSM) | |
dc.contributor | Universidade de São Paulo (USP) | |
dc.date.accessioned | 2016-01-28T16:53:41Z | |
dc.date.available | 2016-01-28T16:53:41Z | |
dc.date.created | 2016-01-28T16:53:41Z | |
dc.date.issued | 2015 | |
dc.identifier | Veterinary and Comparative Oncology, p. 1-9, 2015. | |
dc.identifier | 1476-5829 | |
dc.identifier | http://hdl.handle.net/11449/133112 | |
dc.identifier | 10.1111/vco.12168 | |
dc.identifier | 4272904699684196 | |
dc.identifier | 1128699666207940 | |
dc.identifier | 6404176495306171 | |
dc.identifier | 5431798684243196 | |
dc.identifier | 5359531229053723 | |
dc.description.abstract | Oncolytic virotherapy is a novel strategy for treatment of cancer in humans and companion animals as well. Canine distemper virus (CDV), a paramyxovirus, has proven to be oncolytic through induction of apoptosis in canine-derived tumour cells, yet the mechanism behind this inhibitory action is poorly understood. In this study, three human mammary tumour cell lines and one canine-derived adenofibrosarcoma cell line were tested regarding to their susceptibility to CDV infection, cell proliferation, apoptosis, mitochondrial membrane potential and expression of tumour necrosis factor-alpha-induced protein 8 (TNFAIP8). CDV replication-induced cytopathic effect, decrease of cell proliferation rates, and >45% of infected cells were considered death and/or under late apoptosis/necrosis. TNFAIP8 and CDVM gene expression were positively correlated in all cell lines. In addition, mitochondrial membrane depolarization was associated with increase in virus titres (p < 0.005). Thus, these results strongly suggest that both human and canine mammary tumour cells are potential candidates for studies concerning CDV-induced cancer therapy. | |
dc.language | eng | |
dc.relation | Veterinary and Comparative Oncology | |
dc.relation | 0,946 | |
dc.rights | Acesso restrito | |
dc.source | Currículo Lattes | |
dc.subject | Cancer markers | |
dc.subject | Canine and human mammary tumours | |
dc.subject | Cell phenotype | |
dc.subject | In vitro culture | |
dc.title | Tumour necrosis factor-alpha-induced protein 8 (TNFAIP8) expression associated with cell survival and death in cancer cell lines infected with canine distemper virus | |
dc.type | Artículos de revistas | |