Potent mutagenicity in the Ames test of 2-cyano-4-nitroaniline and 2,6-dicyano-4-nitroaniline, components of disperse dyes

dc.contributorDepartment of Molecular and Cellular Biology, University of Guelph, Guelph, Ontario, Canada.
dc.contributorDepartment of Chemistry, University of Agriculture, Faisalabad, Pakistan.
dc.contributorUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2015-12-07T15:38:20Z
dc.date.available2015-12-07T15:38:20Z
dc.date.created2015-12-07T15:38:20Z
dc.date.issued2015-09-22
dc.identifierEnvironmental And Molecular Mutagenesis, 2015.
dc.identifier1098-2280
dc.identifierhttp://hdl.handle.net/11449/131598
dc.identifier10.1002/em.21983
dc.identifier26394367
dc.description.abstractGenotoxicity data on commercial azo dyes and their components remain sparse, despite their widespread use. We have tested the mutagenicity of 2-cyano-4-nitroaniline (CNNA) and 2,6-dicyano-4-nitroaniline (CNCNNA), components of azo dyes such as Disperse Blue 165 and Disperse Red 73, in Ames test strains. Both compounds are extraordinarily potent frameshift mutagens, with much greater activity than structurally similar dihalonitroanilines and halodinitroanilines. Analysis of the responses of strains over-expressing or deficient in bioactivation enzymes shows that bacterial nitroreductase and acetyl CoA: arylamine N-acetyltransferase are important mediators of the mutagenicity of CNNA and CNCNNA. Environ. Mol. Mutagen., 2015. © 2015 Wiley Periodicals, Inc.
dc.languageeng
dc.publisherWiley-Blackwell
dc.relationEnvironmental And Molecular Mutagenesis
dc.rightsAcesso restrito
dc.sourcePubMed
dc.subjectAmes test
dc.subjectCyanoaromatics
dc.subjectDisperse dyes
dc.subjectNitroanilines
dc.titlePotent mutagenicity in the Ames test of 2-cyano-4-nitroaniline and 2,6-dicyano-4-nitroaniline, components of disperse dyes
dc.typeArtículos de revistas


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