Positive correlations between circulating adiponectin and MMP2 in preeclampsia pregnant

dc.contributorUniversidade Estadual Paulista (Unesp)
dc.contributorUniversidade Estadual de Campinas (UNICAMP)
dc.contributorUniversidade de São Paulo (USP)
dc.date.accessioned2015-12-07T15:32:46Z
dc.date.available2015-12-07T15:32:46Z
dc.date.created2015-12-07T15:32:46Z
dc.date.issued2015
dc.identifierPregnancy Hypertension, v. 5, n. 2, p. 205-208, 2015.
dc.identifier2210-7797
dc.identifierhttp://hdl.handle.net/11449/131222
dc.identifier10.1016/j.preghy.2015.03.001
dc.identifier25943646
dc.description.abstractThe aims of the present study were to compare plasma concentrations of the adiponectin, leptin, metalloproteinases (MMP9 and MMP2) and its tissue inhibitors (TIMP1 and TIMP2) in preeclamptic (PE) and healthy pregnant (HP) groups and correlate them. A total of 105 pregnant women with pre-pregnancy body mass index (BMI) values ⩽ 30 kg/m(2) were enrolled for this study (59 PE and 46 HP). Biomarkers were measured using ELISAs. Adiponectin (32%), leptin (45%), MMP2 (20%), TIMP1 (31%) and TIMP2 (23%) levels were higher in PE compared to HP (all P < 0.05). In addition there were positive correlations between adiponectin and MMP2 (r = 0.33; P = 0.03) and adiponectin and TIMP2 (r = 0.33; P = 0.03) in PE group, but not in HP. Our findings show that adiponectin, leptin, MMP2, TIMP1 and TIMP2 levels are increased in PE and adiponectin may contribute to higher levels of MMP2 and TIMP2 in this disease.
dc.languageeng
dc.publisherElsevier B. V.
dc.relationPregnancy Hypertension
dc.rightsAcesso restrito
dc.sourcePubMed
dc.subjectAdiponectin
dc.subjectLeptin
dc.subjectMetalloproteinase (mmp)-2 and (mmp)-9
dc.subjectPreeclampsia
dc.subjectTissue inhibitor of metalloproteinase (timp)-1 and (timp)-2
dc.titlePositive correlations between circulating adiponectin and MMP2 in preeclampsia pregnant
dc.typeArtículos de revistas


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