dc.contributorUniversidade Federal de São Paulo (UNIFESP)
dc.contributorUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2015-12-07T15:32:34Z
dc.date.available2015-12-07T15:32:34Z
dc.date.created2015-12-07T15:32:34Z
dc.date.issued2015
dc.identifierBioMed Research International, v. 2015, p. 1-18, 2015.
dc.identifier2314-6141
dc.identifierhttp://hdl.handle.net/11449/131203
dc.identifier10.1155/2015/421746
dc.identifierPMC4515490.pdf
dc.identifier4455630076841302
dc.identifier3278495911207882
dc.identifier3278495911207882
dc.identifier26247020
dc.identifierPMC4515490
dc.identifier0000-0001-5756-5828
dc.description.abstractBone tissue is continuously remodeled through the concerted actions of bone cells, which include bone resorption by osteoclasts and bone formation by osteoblasts, whereas osteocytes act as mechanosensors and orchestrators of the bone remodeling process. This process is under the control of local (e.g., growth factors and cytokines) and systemic (e.g., calcitonin and estrogens) factors that all together contribute for bone homeostasis. An imbalance between bone resorption and formation can result in bone diseases including osteoporosis. Recently, it has been recognized that, during bone remodeling, there are an intricate communication among bone cells. For instance, the coupling from bone resorption to bone formation is achieved by interaction between osteoclasts and osteoblasts. Moreover, osteocytes produce factors that influence osteoblast and osteoclast activities, whereas osteocyte apoptosis is followed by osteoclastic bone resorption. The increasing knowledge about the structure and functions of bone cells contributed to a better understanding of bone biology. It has been suggested that there is a complex communication between bone cells and other organs, indicating the dynamic nature of bone tissue. In this review, we discuss the current data about the structure and functions of bone cells and the factors that influence bone remodeling.
dc.languageeng
dc.publisherHindawi Publishing Corporation
dc.relationBioMed Research International
dc.relation0,935
dc.rightsAcesso aberto
dc.sourcePubMed
dc.titleBiology of bone tissue: structure, function, and factors that influence bone cells
dc.typeArtículos de revistas


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