dc.contributorUniversidade de São Paulo (USP)
dc.contributorUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2015-12-07T15:32:19Z
dc.date.available2015-12-07T15:32:19Z
dc.date.created2015-12-07T15:32:19Z
dc.date.issued2015
dc.identifierJournal Of Biophotonics, v. 8, n. 9, p. 723-729, 2015.
dc.identifier1864-0648
dc.identifierhttp://hdl.handle.net/11449/131178
dc.identifier10.1002/jbio.201400081
dc.identifier25319567
dc.description.abstractPhotodynamic therapy (PDT) is used for skin treatments of premalignant and cancer lesions and recognized as a non-invasive technique that combines tissue photosensitization and subsequent exposure to light to induce cell death. However, it is limited to the treatment of superficial lesions, mainly due to the low cream penetration. Therefore, the improvement of transdermal distribution of aminolevulinic acid (ALA) is needed. In this study, the kinetics and homogeneity of production of ALA-induced PpIX after the skin pre-treatment with microneedles rollers of 0.5, 1.0 and 1.5 mm length were investigated. An improvement in homogeneity and production of PpIX was shown in a porcine model. Widefield fluorescence imaging three hours after the topical application of ALA-cream in the combined treatment with microeedles rollers.
dc.languageeng
dc.publisher2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
dc.relationJournal Of Biophotonics
dc.rightsAcesso restrito
dc.sourcePubMed
dc.subjectPpix production
dc.subjectAminolevulinic acid
dc.subjectMicroneedle rollers
dc.subjectPhotodynamic therapy
dc.subjectPorcine skin
dc.titleAssessment of ALA-induced PpIX production in porcine skin pretreated with microneedles
dc.typeArtículos de revistas


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