dc.contributor | Universidade Estadual Paulista (Unesp) | |
dc.contributor | Universidade Federal de São Paulo (UNIFESP) | |
dc.date.accessioned | 2015-12-07T15:32:03Z | |
dc.date.available | 2015-12-07T15:32:03Z | |
dc.date.created | 2015-12-07T15:32:03Z | |
dc.date.issued | 2015 | |
dc.identifier | The Journal Of Venomous Animals And Toxins Including Tropical Diseases, v. 21, p. 1-6, 2015. | |
dc.identifier | 1678-9199 | |
dc.identifier | http://hdl.handle.net/11449/131150 | |
dc.identifier | 10.1186/s40409-015-0022-y | |
dc.identifier | PMC4517494.pdf | |
dc.identifier | 5071093931017493 | |
dc.identifier | 0810837598202634 | |
dc.identifier | 26221123 | |
dc.identifier | PMC4517494 | |
dc.description.abstract | This investigation aimed to evaluate the occurrence of some apoptotic features induced by Leptospira interrogans serovar Icterohaemorrhagiae infection in young BALB/c mice during 2, 4, 7, 10, 14 and 21 days post-infection (dpi). The animals were euthanized and lung, liver and kidneys were harvested to histopathology analysis and immunohistochemistry to caspase-3 antigen detection was performed. Chromatin condensation in kidney and liver tissues, but not in lung tissue, was observed. Caspase-3 reactive cells, mainly characterized as renal epithelial cells, were detected in the days 14 and 21 at high levels when compared to days 2, 4 and 7 (p = 0.025; p < 0.05). Lung sections revealed caspase-3 labeled alveolar cells in 10 and 14 days post-infection was higher than observed at 7 days (p = 0.0497; p < 0.05). Liver sections demonstrated reactive cells at a highest level at 14 and 21 days post-infection when comparison to 2, 4, 7 and 10 days (p = 0.0069; p < 0.05). Our results suggest that infection of L. interrogans induce in kidney, liver and lung an activation of apoptosis mediated by caspase-3 dependent pathway in later phases of infectious process. | |
dc.language | eng | |
dc.relation | The Journal Of Venomous Animals And Toxins Including Tropical Diseases | |
dc.relation | 1.782 | |
dc.relation | 0,573 | |
dc.rights | Acesso aberto | |
dc.source | PubMed | |
dc.subject | Caspases | |
dc.subject | Inflammatory response | |
dc.subject | Leptospirosis | |
dc.subject | Mice | |
dc.subject | Programmed cell death | |
dc.title | Tissue apoptosis in mice infected with Leptospira interrogans serovar Icterohaemorrhagiae | |
dc.type | Artículos de revistas | |