Preliminary X-ray crystallographic studies of a Lys49-phospholipase A(2) homologue from Bothrops pirajai venom complexed with p-bromophenacyl bromide and alpha-tocopherol inhibitors

dc.date.accessioned2015-11-17T15:33:14Z
dc.date.available2015-11-17T15:33:14Z
dc.date.created2015-11-17T15:33:14Z
dc.date.issued2007-01-01
dc.identifierProtein and Peptide Letters, v. 14, n. 7, p. 698-701, 2007.
dc.identifier0929-8665
dc.identifierhttp://hdl.handle.net/11449/130626
dc.identifier10.2174/092986607781483796
dc.identifierWOS:000253577200011
dc.identifier2-s2.0-34548669385
dc.description.abstractPrTX-I, a non-catalytic and myotoxic Lys49-PLA(2) from Bothrops pirajai venom has been crystallized alone and in complex with bromophenacyl bromide (BPB), alpha-tocopherol and alpha-tocopherol acetate inhibitors. These crystals have shown to diffract X-rays between 2.34 and 1.65 angstrom resolution. All complexes crystals are isomorphous and belong to the space group P2(1) whereas native PrTX-I crystals belong to the P3(1)21.
dc.languageeng
dc.publisherBentham Science Publ Ltd
dc.relationProtein and Peptide Letters
dc.relation1.039
dc.relation0,429
dc.rightsAcesso restrito
dc.sourceScopus
dc.subjectα-tocopherol
dc.subjectBothrops pirajai venom
dc.subjectCrystallization
dc.subjectLys49-phospholipase A2
dc.subjectMyotoxity
dc.subjectp-BPB
dc.subjectP-bromophenacyl bromide
dc.subjectVitamin E
dc.subjectX-ray crystallography
dc.subjectAlpha tocopherol
dc.subjectBromide
dc.subjectEnzyme inhibitor
dc.subjectLysine
dc.subjectPhospholipase A
dc.subjectSnake venom
dc.subjectAnimal
dc.subjectChemical structure
dc.subjectChemistry
dc.subjectProtein conformation
dc.subjectSnake
dc.subjectX ray crystallography
dc.subjectAlpha-Tocopherol
dc.subjectAnimals
dc.subjectBothrops
dc.subjectBromides
dc.subjectCrotalid Venoms
dc.subjectCrystallography, X-Ray
dc.subjectEnzyme Inhibitors
dc.subjectLysine
dc.subjectModels, Molecular
dc.subjectPhospholipases A
dc.subjectProtein Conformation
dc.subjectBothrops pirajai
dc.titlePreliminary X-ray crystallographic studies of a Lys49-phospholipase A(2) homologue from Bothrops pirajai venom complexed with p-bromophenacyl bromide and alpha-tocopherol inhibitors
dc.typeArtículos de revistas


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