dc.contributorUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-27T11:22:35Z
dc.date.available2014-05-27T11:22:35Z
dc.date.created2014-05-27T11:22:35Z
dc.date.issued2007-09-27
dc.identifierMicrobiology and Immunology, v. 51, n. 9, p. 787-795, 2007.
dc.identifier0385-5600
dc.identifier1348-0421
dc.identifierhttp://hdl.handle.net/11449/130607
dc.identifier10.1111/j.1348-0421.2007.tb03968.x
dc.identifier2-s2.0-34548816157
dc.description.abstractInfections caused by the genus Staphylococcus are of great importance for human health. Staphylococcus species are divided into coagulase-positive staphylococci, represented by S. aureus, a pathogen that can cause infections of the skin and other organs in immunocompetent patients, and coagulase-negative staphylococci (CNS) which comprise different species normally involved in infectious processes in immunocompromised patients or patients using catheters. Oxacillin has been one of the main drugs used for the treatment of staphylococcal infections; however, a large number of S. aureus and CNS isolates of nosocomial origin are resistant to this drug. Methicillin resistance is encoded by the mecA gene which is inserted in the SCCmec cassette. This cassette is a mobile genetic element consisting of five different types and several subtypes. Oxacillin-resistant strains are detected by phenotypic and genotypic methods. Epidemiologically, methicillin-resistant S. aureus strains can be divided into five large pandemic clones, called Brazilian, Hungarian, Iberian, New York/Japan and Pediatric. The objective of the present review was to discuss aspects of resistance, epidemiology, genetics and detection of oxacillin resistance in Staphylococcus spp., since these microorganisms are increasingly more frequent in Brazil.
dc.languageeng
dc.publisherCenter Academic Publ Japan
dc.relationMicrobiology and Immunology
dc.relation1.335
dc.relation0,764
dc.relation0,764
dc.rightsAcesso restrito
dc.sourceScopus
dc.subjectCoagulase-negative staphylococci
dc.subjectMecA
dc.subjectOxacillin
dc.subjectStaphylococcus aureus
dc.subjectAminoglycoside antibiotic agent
dc.subjectBeta lactam antibiotic
dc.subjectChloramphenicol
dc.subjectCotrimoxazole
dc.subjectDalfopristin plus quinupristin
dc.subjectErythromycin
dc.subjectGentamicin
dc.subjectLinezolid
dc.subjectMacrolide
dc.subjectMeticillin
dc.subjectMinocycline
dc.subjectOxacillin
dc.subjectPenicillin binding protein 2a
dc.subjectPenicillin G
dc.subjectQuinoline derived antiinfective agent
dc.subjectRifampicin
dc.subjectStreptomycin
dc.subjectTetracycline
dc.subjectVancomycin
dc.subjectBacterial gene
dc.subjectBacterial genetics
dc.subjectCoagulase negative Staphylococcus
dc.subjectCoagulase positive Staphylococcus
dc.subjectGene cassette
dc.subjectGene insertion
dc.subjectGene targeting
dc.subjectGenotype
dc.subjectHuman
dc.subjectImmunocompetence
dc.subjectImmunocompromised patient
dc.subjectMec1 gene
dc.subjectMecr1 gene
dc.subjectMethicillin resistant Staphylococcus aureus
dc.subjectMolecular cloning
dc.subjectMolecular epidemiology
dc.subjectNonhuman
dc.subjectPenicillin resistance
dc.subjectPhenotype
dc.subjectRegulator gene
dc.subjectReview
dc.subjectSCCmec gene
dc.subjectStaphylococcus infection
dc.subjectAnti-Bacterial Agents
dc.subjectBrazil
dc.subjectCoagulase
dc.subjectDisease Outbreaks
dc.subjectHumans
dc.subjectMethicillin
dc.subjectMethicillin Resistance
dc.subjectPhenotype
dc.subjectStaphylococcal Infections
dc.subjectStaphylococcus
dc.subjectVancomycin
dc.titleMethicillin resistance in Staphylococcus aureus and coagulase-negative staphylococci: Epidemiological and molecular aspects
dc.typeArtículos de revistas


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