dc.contributorJichi Medical School
dc.contributorNational Institute for Physiological Sciences
dc.contributorUniversidade Estadual Paulista (Unesp)
dc.contributorKumamoto University
dc.date.accessioned2014-05-20T15:25:29Z
dc.date.available2014-05-20T15:25:29Z
dc.date.created2014-05-20T15:25:29Z
dc.date.issued2001-12-01
dc.identifierNeuroscience Research. Clare: Elsevier Sci Ireland Ltd, v. 41, n. 4, p. 365-371, 2001.
dc.identifier0168-0102
dc.identifierhttp://hdl.handle.net/11449/130541
dc.identifier10.1016/S0168-0102(01)00294-2
dc.identifierWOS:000173361300006
dc.description.abstractWe examined the effects of beta-pompilidotoxin (beta-PMTX), a neurotoxin derived from wasp venom. on synaptic transmission in the mammalian central nervous system (CNS). Using hippocampal slice preparations of rodents, we made both extracellular and intracellular recordings from the CA1 pyramidal neurons in response to stimulation of the Schaffer collateral/commissural fibers. Application of 5-10 muM beta-PMTX enhanced excitatory postsynaptic potentials (EPSPs) but suppressed the fast component of the inhibitory postsynaptic potentials (IPSPs). In the presence of 10 muM bicuculline, beta-PMTX potentiated EPSPs that were composed of both non-NMDA and NMDA receptor-mediated potentials. Potentiation of EPSPs was originated by repetitive firings of the prosynaptic axons, causing Summation of EPSPs. In the presence of 10 muM CNQX and 50 muM APV, beta-PMTX suppressed GABA(A) receptor-mediated fast IPSPs but retained GABA(B) receptor-mediated slow IPSPs. Our results suggest that beta-PMTX facilitates excitatory synaptic transmission by a presynaptic mechanism and that it causes overexcitation followed by block of the activity of some population of interneurons which regulate the activity of GABA(A) receptors. (C) 2001 Published by Elsevier B.V. Ireland Ltd and the Japan Neuroscience Society.
dc.languageeng
dc.publisherElsevier B.V.
dc.relationNeuroscience Research
dc.relation2.277
dc.relation1,091
dc.rightsAcesso restrito
dc.sourceScopus
dc.subjectBeta-PMTX
dc.subjectHippocampal slice
dc.subjectNeurotoxin
dc.subjectWasp venom
dc.subject2 amino 5 phosphonovaleric acid
dc.subject4 aminobutyric acid A receptor
dc.subject4 aminobutyric acid receptor blocking agent
dc.subject6 cyano 7 nitro 2,3 quinoxalinedione
dc.subjectAmino acid receptor blocking agent
dc.subjectBenzyl[3 [[1 (3,4 dichlorophenyl)ethyl]amino] 2 hydroxypropyl]phosphinic acid
dc.subjectBicuculline
dc.subjectBicuculline methochloride
dc.subjectDrug derivative
dc.subjectN methyl dextro aspartic acid receptor
dc.subjectNeurotoxin
dc.subjectPhosphinic acid derivative
dc.subjectPompilidotoxin beta
dc.subjectPropanolamine derivative
dc.subjectReceptors, GABA A
dc.subjectReceptors, N Methyl D Aspartate
dc.subjectWasp venom
dc.subjectAction potential
dc.subjectAnimal
dc.subjectChemistry
dc.subjectClassification
dc.subjectComparative study
dc.subjectCytology
dc.subjectDendrite
dc.subjectDrug effect
dc.subjectExcitatory postsynaptic potential
dc.subjectGerbil
dc.subjectHippocampus
dc.subjectInterneuron
dc.subjectIsolation and purification
dc.subjectNerve cell
dc.subjectPhysiology
dc.subjectPyramidal nerve cell
dc.subjectRat
dc.subjectRat strain
dc.subjectSodium channel
dc.subjectSynaptic transmission
dc.subject2-Amino-5-phosphonovalerate
dc.subject6-Cyano-7-nitroquinoxaline-2,3-dione
dc.subjectAction Potentials
dc.subjectAnimal
dc.subjectBicuculline
dc.subjectComparative Study
dc.subjectDendrites
dc.subjectExcitatory Amino Acid Antagonists
dc.subjectExcitatory Postsynaptic Potentials
dc.subjectGABA Antagonists
dc.subjectGerbillinae
dc.subjectHippocampus
dc.subjectInterneurons
dc.subjectNeurons
dc.subjectNeurotoxins
dc.subjectPhosphinic Acids
dc.subjectPropanolamines
dc.subjectPyramidal Cells
dc.subjectRats
dc.subjectRats, Wistar
dc.subjectReceptors, GABA-A
dc.subjectReceptors, N-Methyl-D-Aspartate
dc.subjectSodium Channels
dc.subjectSupport, Non-U.S. Gov't
dc.subjectSynaptic Transmission
dc.subjectWasp Venoms
dc.titleModulation of synaptic transmission in hippocampal CA1 neurons by a novel neurotoxin (beta-pompilidotoxin) derived from wasp venom
dc.typeArtículos de revistas


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