dc.contributor | Universidade Federal de São Carlos (UFSCar) | |
dc.contributor | Universidade Estadual Paulista (Unesp) | |
dc.contributor | Universidade de São Paulo (USP) | |
dc.contributor | Universidade Federal do Rio de Janeiro (UFRJ) | |
dc.contributor | Universidade Federal de Uberlândia (UFU) | |
dc.date.accessioned | 2015-10-21T20:56:26Z | |
dc.date.available | 2015-10-21T20:56:26Z | |
dc.date.created | 2015-10-21T20:56:26Z | |
dc.date.issued | 2015-01-08 | |
dc.identifier | Polyhedron. Oxford: Pergamon-elsevier Science Ltd, v. 85, p. 376-382, 2015. | |
dc.identifier | 0277-5387 | |
dc.identifier | http://hdl.handle.net/11449/129367 | |
dc.identifier | 10.1016/j.poly.2014.08.057 | |
dc.identifier | WOS:000347582900047 | |
dc.description.abstract | Three promising antimycobacterium tuberculosis ruthenium(II) complexes with the deprotonated ligands 2-hydroxynicotinic acid (2-OHnicH), 6-hydroxynicotinic acid (6-OHnicH) and 3-hydroxypicolinic acid (3-OHpicH) were synthesized and characterized. Structural analysis revealed three different coordination modes depending of the hydroxypyridinecarboxylate ligand. In the complex [Ru(2-OHnic)(dppb)(bipy)PF6 (1), the 2-OHnic anion is coordinated by the O,O-chelating mode (via carboxylate group and phenolate oxygen), in the Ru(6-OHnic)(dppb)(bipy)]PF6 (2) a O-O chelation by the carboxylate group is observed for the 6-OHnic ligand and for the complex [Ru(3-OHpic)(dppb)(bipy))PF6 (3) a N,O-chelating mode (via carboxylate) occurs to the 3-OHpic anion. The compounds were evaluated for activity against Mycobacterium tuberculosis H(37)Rv ATCC 27294 using Resazurin Microtitre Assay (REMA) plate method and cytotoxicity in VERO CCL-81 cell line. All the synthesized compounds exhibited good antimycobacterial activity and a completely lack of cytotoxicity activity, indicating a good selectivity index. (C) 2014 Elsevier Ltd. All rights reserved. | |
dc.language | eng | |
dc.publisher | Elsevier B.V. | |
dc.relation | Polyhedron | |
dc.relation | 2.067 | |
dc.relation | 0,472 | |
dc.rights | Acesso aberto | |
dc.source | Web of Science | |
dc.subject | Mycobacterium tuberculosis | |
dc.subject | Cytotoxicity | |
dc.subject | Ruthenium(II) complexes | |
dc.subject | Metallodrugs | |
dc.subject | Hydroxypyridinecarboxylates | |
dc.title | Ruthenium(II) complexes with hydroxypyridinecarboxylates: screening potential metallodrugs against Mycobacterium tuberculosis | |
dc.type | Artículos de revistas | |