Nitric Oxide and Nitroxyl Products from the Reaction of L-Cysteine with trans-[RuNO(NH3)(4)P(OEt)(3)](PF6)(3)

dc.contributorUniversidade de São Paulo (USP)
dc.contributorUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2015-10-21T20:23:18Z
dc.date.available2015-10-21T20:23:18Z
dc.date.created2015-10-21T20:23:18Z
dc.date.issued2015-02-01
dc.identifierEuropean Journal Of Inorganic Chemistry. Weinheim: Wiley-v C H Verlag Gmbh, v. 2015, n. 6, p. 1005-1011, 2015.
dc.identifier1434-1948
dc.identifierhttp://hdl.handle.net/11449/129112
dc.identifier10.1002/ejic.201402992
dc.identifierWOS:000349976200013
dc.description.abstractThe reaction between the trans-[RuNO(NH3)(4)P(OEt)(3)](PF6)(3) and L-cysteine (RS-) was studied over a pH range of 2.0-7.4. In this reaction, the concentrations of NO and HNO produced varied as a function of the pH of the solution. The first step of this reaction proceeded quickly [k(1) = (3.5 +/- 0.3)x10(3) M-1 s(-1), pH = 3.5, 25 degrees C] and resulted in the formation of trans-[Ru(NH3)(4)P(OEt)(3)N(O)SR](2+), which dissociated to yield trans-[Ru(NH3)(4)P(OEt)(3)NO](2+) and RS. However, trans-[Ru(NH3)(4)P(OEt)(3)N(O)SR](n-1) can react with a second L-cysteine, yielding trans-[Ru(NH3)(4)P(OEt)(3)N(O)(SR)(2)](+) [k(2) = (3.6 +/- 0.1) M(-1)s(-1), pH = 3.5, 25 degrees C]. Therefore, the trans-[Ru(NH3)(4)P(OEt)(3)NO](2+) species released NO and the trans-[Ru(NH3)(4)P(OEt)(3)N(O)(SR)(2)](n-2) species released HNO.
dc.languageeng
dc.publisherWiley-Blackwell
dc.relationEuropean Journal Of Inorganic Chemistry
dc.relation2.507
dc.relation0,828
dc.rightsAcesso restrito
dc.sourceWeb of Science
dc.subjectNitric oxide
dc.subjectNitroxyl
dc.subjectNitrogen oxides
dc.subjectRuthenium
dc.subjectKinetics
dc.subjectMedicinal chemistry
dc.titleNitric Oxide and Nitroxyl Products from the Reaction of L-Cysteine with trans-[RuNO(NH3)(4)P(OEt)(3)](PF6)(3)
dc.typeArtículos de revistas


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