Artículos de revistas
Antioxidants and biomarkers of oxidative damage in the saliva of patients with Down's syndrome
Fecha
2015-04-01Registro en:
Archives Of Oral Biology. Oxford: Pergamon-elsevier Science Ltd, v. 60, n. 4, p. 600-605, 2015.
0003-9969
10.1016/j.archoralbio.2014.09.013
WOS:000351790000011
4716676611330311
9304600166583100
0000-0003-0987-5594
Autor
Universidade Estadual Paulista (Unesp)
Institución
Resumen
Background: The aim of this study was to investigate enzymatic and non-enzymatic antioxidant systems and levels of biomarker levels of oxidative damage in the saliva of patients with Down's syndrome (DS).Methods: Saliva samples were collected from 30 patients with DS and control group (age: 1424 years). Subsequently, the concentrations of superoxide dismutase, concentration of malondialdehyde, carbonylated proteins, uric acid, vitamin C and total protein, peroxidase activity and total antioxidant capacity were analyzed.Results: Patients with DS presented significantly higher concentrations of superoxide dismutase, higher levels of malondialdehyde and salivary total protein content than controls (p < 0.05). Conversely, no difference in carbonylated proteins or antioxidants (uric acid, vitamin C, peroxidase, and total antioxidant capacity) was observed between DS patients and controls (p > 0.05).Conclusion: Patients with DS are more vulnerable to oxidative stress in saliva as indicated by the significant increase in malondialdehyde and superoxide dismutase concentrations found in this study.