Using the comet and micronucleus assays for genotoxicity studies: a review

dc.contributorUniversidade de São Paulo (USP)
dc.contributorUniversidade Estadual Paulista (Unesp)
dc.contributorUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2015-08-21T17:54:02Z
dc.date.available2015-08-21T17:54:02Z
dc.date.created2015-08-21T17:54:02Z
dc.date.issued2015
dc.identifierBiomedicine & Pharmacotherapy, v. 72, p. 74-82, 2015.
dc.identifier0753-3322
dc.identifierhttp://hdl.handle.net/11449/127163
dc.identifier10.1016/j.biopha.2015.04.004
dc.identifier3892896473273324
dc.identifier0000-0001-7083-5626
dc.description.abstractPhysical, chemical and biological agents can act in the DNA, resulting in mutation involved in cancer. Thus, genotoxic tests are required by regulatory agencies in order to evaluate potential risk of cancer. Among these tests, the comet assay (CA) and micronucleus assay (MNA) are the most commonly used. However, there are different protocols and recommendations already published. This is the first review, after the inclusion of CA in S2R1 guidance and OECD 489, which summarizes the main technical recommendations of both CA and MNA.
dc.languageeng
dc.relationBiomedicine & Pharmacotherapy
dc.relation3.457
dc.relation0,951
dc.rightsAcesso restrito
dc.sourceCurrículo Lattes
dc.subjectGenotoxicity tests
dc.subjectComet assay
dc.subjectMicronucleus assay
dc.subjectMutagenesis
dc.titleUsing the comet and micronucleus assays for genotoxicity studies: a review
dc.typeArtículos de revistas


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