Artículos de revistas
Desenvolvimento e caracterização de nanocápsulas de poli(l-lactídeo) contendo benzocaína
Fecha
2010Registro en:
Química Nova, v. 33, n. 1, p. 65-69, 2010.
0100-4042
ISSN0100-4042-2010-33-01-65-69.pdf
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1509480515046572
5343212477106568
6434758592103771
5228846314663888
2188736885721242
0000-0002-2042-018X
0000-0002-0284-5782
Autor
Universidade Estadual Paulista (Unesp)
Universidade Estadual de Campinas (UNICAMP)
Universidade Federal do ABC (UFABC)
Institución
Resumen
In this paper we describe the preparation poly (L-lactide) (PLA) nanocapsules as a drug delivery system for the local anesthetic benzocaine. The characterization and in vitro release properties of the system were investigated. The characterization results showed a polydispersity index of 0.14, an average diameter of 190.1± 3 nm, zeta potential of –38.5 mV and an entrapment efficiency of 73%. The release profile of Benzocaine loaded in PLA nanocapsules showed a significant different behavior than that of the pure anesthetic in solution. This study is important to characterize a drug release system using benzocaine for application in pain treatment.