dc.contributor | Universidade Estadual Paulista (Unesp) | |
dc.date.accessioned | 2015-03-18T15:56:56Z | |
dc.date.available | 2015-03-18T15:56:56Z | |
dc.date.created | 2015-03-18T15:56:56Z | |
dc.date.issued | 2013-11-01 | |
dc.identifier | Turkish Journal Of Pediatrics. Ankara: Turkish J Pediatrics, v. 55, n. 6, p. 598-605, 2013. | |
dc.identifier | 0041-4301 | |
dc.identifier | http://hdl.handle.net/11449/117802 | |
dc.identifier | WOS:000341415700005 | |
dc.identifier | 8510423269540465 | |
dc.identifier | 2559637400719543 | |
dc.identifier | 8499437381595614 | |
dc.identifier | 1197755531108177 | |
dc.identifier | 4940791909535775 | |
dc.identifier | 1446883241749717 | |
dc.identifier | 0000-0001-5478-4996 | |
dc.identifier | 0000-0003-1380-7527 | |
dc.description.abstract | This study aimed to evaluate the levels of pro-and anti-inflammatory cytokines in umbilical cord blood of preterm neonates who developed focal early-onset infection (EOI) after preterm premature rupture of membranes (PPROM). This is a prospective study conducted on 46 preterm infants from mothers with PPROM. The cytokines were measure by flow cytometry. Newborns were classified into two groups as focal EOI (n=19) and non-infected (n=27). Interleukin (IL)-6 and IL-8 levels were higher, whereas IL-10 and IL-12 p70 levels were lower in the EOI when compared to the non-infected group. The best combination of cytokines was IL-6+IL-8, with a diagnostic accuracy of 0.97. Focal EOI after PPROM is associated with increased levels of IL-6 and IL-8 and diminished IL-10 and IL-12 in the cord blood of preterm infants. Combined assessment of IL-6 and IL-8 in cord blood may provide an additional tool for identifying preterm infants who develop EOI after PPROM. | |
dc.language | eng | |
dc.publisher | Turkish J Pediatrics | |
dc.relation | Turkish Journal Of Pediatrics | |
dc.relation | 0.187 | |
dc.relation | 0,173 | |
dc.rights | Acesso aberto | |
dc.source | Web of Science | |
dc.subject | early infection | |
dc.subject | in vivo inflammation | |
dc.subject | cytokine | |
dc.subject | innate immunity | |
dc.subject | infant | |
dc.subject | premature | |
dc.title | Cord blood cytokine levels in focal early-onset neonatal infection after preterm premature rupture of membranes | |
dc.type | Artículos de revistas | |