Bone Morphogenetic Proteins: Structure, biological function and therapeutic applications

dc.contributorUniversidade de São Paulo (USP)
dc.contributorUniversidade Federal Fluminense (UFF)
dc.contributorUniversidade Estadual Paulista (Unesp)
dc.contributorNatl Inst Metrol Qual & Technol
dc.date.accessioned2015-03-18T15:53:15Z
dc.date.available2015-03-18T15:53:15Z
dc.date.created2015-03-18T15:53:15Z
dc.date.issued2014-11-01
dc.identifierArchives Of Biochemistry And Biophysics. New York: Elsevier Science Inc, v. 561, p. 64-73, 2014.
dc.identifier0003-9861
dc.identifierhttp://hdl.handle.net/11449/116393
dc.identifier10.1016/j.abb.2014.07.011
dc.identifierWOS:000342863300009
dc.description.abstractBone Morphogenetic Proteins (BMPs) are multifunctional secreted cytokines, which belong to the TGF-beta superfamily. These glycoproteins act as a disulfide-linked homo- or heterodimers, being potent regulators of bone and cartilage formation and repair, cell proliferation during embryonic development and bone homeostasis in the adult. BMPs are promising molecules for tissue engineering and bone therapy. The present review discusses this family of proteins, their structure and biological function, their therapeutic applications and drawbacks, their effects on mesenchymal stem cells differentiation, and the cell signaling pathways involved in this process. (C) 2014 Published by Elsevier Inc.
dc.languageeng
dc.publisherElsevier B.V.
dc.relationArchives Of Biochemistry And Biophysics
dc.relation3.118
dc.relation1,350
dc.rightsAcesso restrito
dc.sourceWeb of Science
dc.subjectBone Morphogenetic Proteins
dc.subjectOsteogenesis inducing proteins
dc.subjectPeptide growth factors
dc.subjectBone repair
dc.subjectExtracellular matrix
dc.subjectTissue engineering
dc.titleBone Morphogenetic Proteins: Structure, biological function and therapeutic applications
dc.typeArtículos de revistas


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