Artículos de revistas
A magnetically drivable nanovehicle for curcumin with antioxidant capacity and MRI relaxation properties
Date
2014-09-08Registration in:
Chemistry-a European Journal. Weinheim: Wiley-v C H Verlag Gmbh, v. 20, n. 37, p. 11913-11920, 2014.
0947-6539
10.1002/chem.201402820
WOS:000341630500040
Author
Univ Padua
Universidade Estadual Paulista (Unesp)
Palacky Univ
Graz Univ Technol
Institutions
Abstract
Curcumin possesses wide-ranging anti-inflammatory and anti-cancer properties and its biological activity can be linked to its potent antioxidant capacity. Superparamagnetic maghemite (gamma-Fe2O3), called surface-active maghemite nanoparticles (SAMNs) were surface-modified with curcumin molecules, due to the presence of under-coordinated Fe-III atoms on the nanoparticle surface. The so-obtained curcumin-modified SAMNs (SAMN@curcumin) had a mean size of 13 +/- 4 nm. SAMN@curcumin was characterized by transmission and scanning electron microscopy, UV/Vis, FTIR, and Mossbauer spectroscopy, X-ray powder diffraction, bulk susceptibility (SQUID), and relaxometry measurements (MRI imaging). The high negative contrast proclivity of SAMN@curcumin to act as potential contrast agent in MRI screenings was also tested. Moreover, the redox properties of bound curcumin were probed by electrochemistry. SAMN@curcumin was studied in the presence of different electroactive molecules, namely hydroquinone, NADH and ferrocyanide, to assess its redox behavior. Finally, SAMN@curcumin was electrochemically probed in the presence of hydrogen peroxide, demonstrating the stability and reactivity of bound curcumin.