dc.contributorUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-12-03T13:10:52Z
dc.date.available2014-12-03T13:10:52Z
dc.date.created2014-12-03T13:10:52Z
dc.date.issued2014-02-15
dc.identifierPhytomedicine. Jena: Elsevier Gmbh, Urban & Fischer Verlag, v. 21, n. 3, p. 240-246, 2014.
dc.identifier0944-7113
dc.identifierhttp://hdl.handle.net/11449/112601
dc.identifier10.1016/j.phymed.2013.09.001
dc.identifierWOS:000334012400007
dc.identifier1697547325096457
dc.description.abstractBackground: Coumarins, also known as benzopyrones, are plant-derived products with several pharmacological properties, including antioxidant and anti-inflammatory activities. Based on the wide distribution of coumarin derivatives in plant-based foods and beverages in the human diet, our objective was to evaluate both the antioxidant and intestinal anti-inflammatory activities of six coumarin derivatives of plant origin (scopoletin, scoparone, fraxetin, 4-methyl-umbeliferone, esculin and daphnetin) to verify if potential intestinal anti-inflammatory activity was related to antioxidant properties.Methods: Intestinal inflammation was induced by intracolonic instillation of TNBS in rats. The animals were treated with coumarins by oral route. The animals were killed 48 h after colitis induction. The colonic segments were obtained after laparotomy and macroscopic and biochemical parameters (determination of glutathione level and myeloperoxidase and alkaline phosphatase activities) were evaluated. The antioxidant properties of these coumarins were examined by lipid peroxidation and DPPH assays.Results: Treatment with esculin, scoparone and daphnetin produced the best protective effects. All coumarin derivatives showed antioxidant activity in the DPPH assay, while daphnetin and fraxetin also showed antioxidant activity by inhibiting lipid peroxidation. Coumarins, except 4-methyl-umbeliferone, also showed antioxidant activity through the counteraction of glutathione levels or through the inhibition of myeloperoxidase activity.Discussion: The intestinal anti-inflammatory activity of coumarin derivatives were related to their antioxidant properties, suggesting that consumption of coumarins and/or foods rich in coumarin derivatives, particularly daphnetin, esculin and scoparone, could prevent intestinal inflammatory disease. (C) 2013 Elsevier GmbH. All rights reserved.
dc.languageeng
dc.publisherElsevier B.V.
dc.relationPhytomedicine
dc.relation3.610
dc.relation1,087
dc.rightsAcesso restrito
dc.sourceWeb of Science
dc.subjectCoumarin derivatives
dc.subjectAntioxidant
dc.subjectInflammatory bowel disease
dc.titleAntioxidant and intestinal anti-inflammatory effects of plant-derived coumarin derivatives
dc.typeArtículos de revistas


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