dc.contributorUniversidade Federal do Rio Grande do Norte (UFRN)
dc.contributorUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-12-03T13:09:13Z
dc.date.available2014-12-03T13:09:13Z
dc.date.created2014-12-03T13:09:13Z
dc.date.issued2013-05-01
dc.identifierJournal Of Thermal Analysis And Calorimetry. Dordrecht: Springer, v. 112, n. 2, p. 555-565, 2013.
dc.identifier1388-6150
dc.identifierhttp://hdl.handle.net/11449/112079
dc.identifier10.1007/s10973-012-2580-3
dc.identifierWOS:000318292400004
dc.identifier9114495952533044
dc.description.abstractDrug-polymer interactions, structural properties, thermal behavior, and stability of biodegradable microparticles are fundamental aspects in the developing of new polymeric drug delivery systems. In this study, poly (d,l-lactide-co-glycolide) (PLGA) microparticles containing methotrexate (MTX) were successfully obtained by spray drying. Scanning electronic microscopy, differential scanning calorimetry (DSC), thermogravimetry (TG), X-ray diffraction (XRD), and drug-loading efficiency were used to investigate the effect of drug-polymer ratio and its interactions, in a new MTX-loaded PLGA spray-dried microparticles. High levels of encapsulation efficiency (about 90 %) and a prevalent spherical shape were identified for different drug-polymer ratios used (9, 18, and 27 % m/m). The thermal analyses (DSC and TG) and XRD indicate that MTX is homogeneously distributed in the polymeric matrix, with a prevalent amorphous state in a stable molecular dispersion. Therefore, a correlation between drug content and the structural-thermal properties of drug-loaded PLGA microparticles was established using the thermal analysis data. The biodegradable microparticle leads to an increment of thermal stability of MTX, confirming that spray drying is an efficient process for obtaining MTX-loaded PLGA microparticles.
dc.languageeng
dc.publisherSpringer
dc.relationJournal of Thermal Analysis and Calorimetry
dc.relation2.209
dc.relation0,587
dc.rightsAcesso restrito
dc.sourceWeb of Science
dc.subjectMethotrexate
dc.subjectPLGA microparticles
dc.subjectSpray drying
dc.subjectThermal analysis
dc.titleStructural and thermal properties of spray-dried methotrexate-loaded biodegradable microparticles
dc.typeArtículos de revistas


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