Evaluation of Syngonanthus nitens (Bong.) Ruhl. extract as antifungal and in treatment of vulvovaginal candidiasis

dc.contributorUniversidade Estadual Paulista (Unesp)
dc.contributorChemistry Institute
dc.contributorNational University of Cordoba
dc.date.accessioned2014-05-27T11:30:49Z
dc.date.available2014-05-27T11:30:49Z
dc.date.created2014-05-27T11:30:49Z
dc.date.issued2013-10-01
dc.identifierMedical Mycology, v. 51, n. 7, p. 673-682, 2013.
dc.identifier1369-3786
dc.identifier1460-2709
dc.identifierhttp://hdl.handle.net/11449/76768
dc.identifier10.3109/13693786.2013.795294
dc.identifierWOS:000324538900001
dc.identifier2-s2.0-84884330991
dc.identifier4930795298045665
dc.identifier4910754838277580
dc.identifier0000-0003-3032-2556
dc.description.abstractThe purpose of this study was to evaluate the in vitro anticandidal activity of a methanolic extract of Syngonanthus nitens scapes against different Candida species and clinical isolates from patients with vulvovaginal candidiasis (VVC), and its effect in vivo in the treatment of vaginal infection. Chemical characterization of the extract was performed by HPLC-UV analyses and showed the presence of flavones derivatives. The extract was effective against several Candida strains from our collection and species recovered from VVC patients, and was able to inhibit the yeast-hyphal transition. No cytotoxic activity against human female reproductive tract epithelial cells and no hemolytic activity against human red blood cells were observed. In the in vivo model of VVC, we evaluated the efficacy of the intravaginal treatment with a cream containing the extract at doses of 0.5, 1.0 and 2.0%. The treatment eradicated the vaginal fungal burden in infected rats after 8 days of treatment. S. nitens extract could be considered as an effective and non-toxic natural antifungal agent in the treatment of vulvovaginal candidiasis. © 2013 ISHAM.
dc.languageeng
dc.relationMedical Mycology
dc.relation2.799
dc.relation0,973
dc.relation0,973
dc.rightsAcesso restrito
dc.sourceScopus
dc.subjectAnticandidal activity
dc.subjectSyngonanthus nitens
dc.subjectVulvovaginal candidiasis
dc.subjectYeast-hyphal transition
dc.subjectamphotericin B
dc.subjectantifungal agent
dc.subjectflavone derivative
dc.subjectflavonoid
dc.subjectplant extract
dc.subjectSyngonanthus nitens extract
dc.subjectunclassified drug
dc.subjectanimal experiment
dc.subjectanimal model
dc.subjectantifungal activity
dc.subjectantifungal susceptibility
dc.subjectCandida albicans
dc.subjectCandida krusei
dc.subjectCandida parapsilosis
dc.subjectCandida tropicalis
dc.subjectcell damage
dc.subjectcontrolled study
dc.subjectcream
dc.subjectdrug cytotoxicity
dc.subjectdrug efficacy
dc.subjectepithelium cell
dc.subjectEriocaulaceae
dc.subjecterythrocyte
dc.subjectevaluation
dc.subjectfemale
dc.subjectfemale genital system
dc.subjectfungus growth
dc.subjectgrowth inhibition
dc.subjecthemolysis
dc.subjecthigh performance liquid chromatography
dc.subjecthuman
dc.subjecthuman cell
dc.subjectin vitro study
dc.subjectminimum inhibitory concentration
dc.subjectnonhuman
dc.subjectrat
dc.subjectultraviolet spectroscopy
dc.subjectvagina candidiasis
dc.subjectvaginitis
dc.titleEvaluation of Syngonanthus nitens (Bong.) Ruhl. extract as antifungal and in treatment of vulvovaginal candidiasis
dc.typeArtículos de revistas


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